APPLICATION OF CHITOSAN IN THE FORMULATION OF DERMATOLOGICAL HYDROGELS PREPARED ON THE BASIS OF MACROMOLECULAR COMPOUNDS

• Authors: Maria Szcześniak , Bożena Grimling , Jan Meler , Bożena Karolewicz
• Languages of publication: EN

Abstracts

EN

The effect of chitosan concentration on the properties of dermatological preparations prepared with 2% methylcellulose and 10% polyvinylpyrrolidone was studied. As the levels of chitosan, propylene glycol-1,2 and glycerol increased, the hardness, consistency and cohesiveness of the hydrophilic gels increased, while the dissipation capacity decreased. Gels based on methylcellulose and chitosan, compared to formulations containing polyvinylpyrrolidone, have a higher rate of loss of volatile compounds, higher pH values for 1,2-propylene glycol formulation and higher texture parameters. The tested hydrogels have good rheological properties, allowing extrusion from the tube and spreading on the skin.

Keywords

EN

chitosan; hydrogels; rheological parameters

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2018
• Volume: 23
• Pages: 179 - 184

Contributors

author

Maria Szcześniak

• Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University

author

Bożena Grimling

• Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University

author

Jan Meler

• Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University

author

Bożena Karolewicz

• Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University

References

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• Document Type: article