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2018 | 23 | 179 - 184
Article title

APPLICATION OF CHITOSAN IN THE FORMULATION OF DERMATOLOGICAL HYDROGELS PREPARED ON THE BASIS OF MACROMOLECULAR COMPOUNDS

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EN
Abstracts
EN
The effect of chitosan concentration on the properties of dermatological preparations prepared with 2% methylcellulose and 10% polyvinylpyrrolidone was studied. As the levels of chitosan, propylene glycol-1,2 and glycerol increased, the hardness, consistency and cohesiveness of the hydrophilic gels increased, while the dissipation capacity decreased. Gels based on methylcellulose and chitosan, compared to formulations containing polyvinylpyrrolidone, have a higher rate of loss of volatile compounds, higher pH values for 1,2-propylene glycol formulation and higher texture parameters. The tested hydrogels have good rheological properties, allowing extrusion from the tube and spreading on the skin.
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Year
Volume
23
Pages
179 - 184
Physical description
Contributors
  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University
author
  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University
  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University
References
  • [1] Orłowska J., Szcześniak P., Orszulak - Michalak D; (2011) Chitin derivatives – application in tissue engineering and design for active dressings. Farm. Pol. 67 (12), 867 – 872.
  • [2] Kumar A., Vimal A., Kumar A; (2016) Why Chitosan? From properties to perspective of mucosal drugdelivery. Int J Biol Macromol, 91, 615 – 622. DOI: 10.1016/j.ijbiomac.2016.05.054.
  • [3] Patrulea V., Ostafe V., Borchard G., Jordan O; ( 2015) Chitosan as a starting material for wound healing applications. Eur J Pharm Biopharm, 97, 417 – 426. DOI:10.1016/j.ejpb.2015.08.004
  • [4] Korytkowska-Wałach A., Emiga-Matuszowicz M., Łukaszczyk J; ( 2015) Polymeric in situ forming systems for biomedical applications. Part II. Injectable hydrogel systems. Polimery 60.7-8, 435-445. DOI: dx.doi.org/10.14314/polimery
  • [5] Mazurek P., Kuliński S., Gosk J; ( 2013) The Possibilities of Using a Chitin and Chitosan in Wounds Treatment. Polim. Med.43, 43,297-302. [6] Szcześniak M., Pluta J; (2012) Hydrożele. Farm. Pol. 7, 458-461. [7] Szcześniak M., Pluta J; (2013) The effect of selected excipients on the properties hydro gels on the basis Carbopol 934 P. Polim Med 43, 29-34. [8] Szcześniak M., Pluta J; (2011) Influence of polymers on hydrogels with hydrocortisone properties. Polim Med 41, 2, 43-48.
  • [9] Szcześniak M., Grimling B., Meler J., Karolewicz B; (2017) The influence of selected polymers on the rheological properties of hydrogels with chitosan applied on the skin.. Progress on Chemistry and Application of Chitin and its Derivatives, Volume XXII, 201-206. DOI:10.15259/PCACD.2220
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-e3e91f9a-1be3-4151-97f5-6064ebe3cd6d
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