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Journal
2019 | 9 | 1 | 27-30
Article title

Severe vascular and neurological complications after hematopoietic stem cell transplantation with reduced intensity conditioning

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Abstracts
EN
It is well established that the benefit of myeloablative ALLO-HSCT can be associated with a potential high risk of procedure-related toxicity. The objective of this report is the analysis of complications in a 17-year-old girl with AML previously treated for medulloblastoma and myelodysplastic syndrome. Thiotepa, fludarabine, treosulfan and thymoglobuline were used in conditioning regimen. During conditioning neurological complications have occurred. MRI and CT scan results revealed the coexistence of PRES with the left internal carotid artery thrombosis. The effect of fludarabine on endothelial cells could possibly contribute to irreversible CNS damage and death in presented case.
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Journal
Year
Volume
9
Issue
1
Pages
27-30
Physical description
Contributors
  • Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland, k.czyzewski@cm.umk.pl
  • Student Scientific Society at Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
  • Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
  • Department of Radiology and Diagnostic Imagining, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
  • Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
References
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  • 2. Barba P, Pinana JL, Valcarcel D et al. Early and late neurological complications after reduced-intensity conditioning allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2009; 15(11): 1439-1446.
  • 3. Beitinjaneh A, McKinney AM, Cao Q et al. Toxic leukoencephalopathy following fludarabine-associated hematopoietic cell transplantation. Biol Blood Marrow Transplant 2011; 17(3): 300-308.
  • 4. Annaloro C, Costa A, Fracchiolla NS et al. Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report. Clin Case Rep 2015; 3(7): 650-655.
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  • 15. Eder S, Labopin M, Finke J et al. Safety and efficacy of thiotepa-based conditioning for allogeneic transplantation in AML: a survey from the ALWP of the EBMT. Bone Marrow Transplant 2017; 52(2): 238-244.
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  • 17. Slatter MA, Boztug H, Potschger U et al. Treosulfan-based conditioning regimens for allogeneic haematopoietic stem cell transplantation in children with non-malignant diseases. Bone Marrow Transplant 2015; 50(12): 1536-1541.
Document Type
article
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Identifiers
YADDA identifier
bwmeta1.element.psjd-e07961dd-57d0-472c-a771-3679ab3c31c3
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