Severe vascular and neurological complications after hematopoietic stem cell transplantation with reduced intensity conditioning

• Authors: Krzysztof Czyżewski , Paulina Nierychlewska , Monika Richert-Przygońska , Jakub Cieściński , Jan Styczyński
• Languages of publication: EN

Abstracts

EN

It is well established that the benefit of myeloablative ALLO-HSCT can be associated with a potential high risk of procedure-related toxicity. The objective of this report is the analysis of complications in a 17-year-old girl with AML previously treated for medulloblastoma and myelodysplastic syndrome. Thiotepa, fludarabine, treosulfan and thymoglobuline were used in conditioning regimen. During conditioning neurological complications have occurred. MRI and CT scan results revealed the coexistence of PRES with the left internal carotid artery thrombosis. The effect of fludarabine on endothelial cells could possibly contribute to irreversible CNS damage and death in presented case.

Keywords

EN

ALLO-HSCT; PRES; fludarabine; neurotoxicity; reduced intensity conditioning

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Education
• Journal: OncoReview
• Year: 2019
• Volume: 9
• Issue: 1
• Pages: 27-30

Contributors

author

Krzysztof Czyżewski

• Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland

author

Paulina Nierychlewska

• Student Scientific Society at Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland

author

Monika Richert-Przygońska

• Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland

author

Jakub Cieściński

• Department of Radiology and Diagnostic Imagining, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland

author

Jan Styczyński

• Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland

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• Document Type: article