Znaczenie epigenetyki w patogenezie czerniaka

• Authors: Ewa Chodurek , Karolina Gołąbek , Joanna Orchel , Arkadiusz Orchel , Zofia Dzierżewicz

Title variants

EN

The role of epigenetics in the pathogenesis of melanoma

• Languages of publication: PL

Abstracts

PL

Przez pojęcie epigenetyka należy rozumieć mechanizmy wpływające na regulację i modyfi kację ekspresji materiału genetycznego, jednocześnie niezmieniające sekwencji nukleotydów. Mechanizmy te obejmują zarówno metylację DNA, jak i modyfi kacje histonów. W artykule dokonano przeglądu aktualnych poglądów dotyczących zaburzeń procesów hiperi hipometylacji DNA oraz acetylacji histonów w patogenezie czerniaka, związanych z genami kontrolującymi cykl komórkowy, różnicowanie, naprawę DNA, apoptozę, sygnalizację komórkową, angiogenezę, metabolizm ksenobiotyków i powstawanie przerzutów. Ponadto przedstawiono nowe strategie leczenia czerniaka związane z epigenetyką.

EN

Epigenetics represents the mechanisms that infl uence the regulation and modifi cation of the expression of genetic material not related to the alterations in DNA sequences. These mechanisms include both DNA methylation and histone modifi cations. In the present article, we review current views on the role of aberrations of DNA hyper- and hypomethylation processes and the acetylation of histones, associated with genes that control the cell cycle, cell diff erentiation, DNA repair, apoptosis, cell signaling, angiogenesis, metabolism of xenobiotics and invasion, in the pathogenesis of melanoma. In addition, new strategies for treatment of melanoma associated with epigenetics are presented.

Keywords

EN

DNA methylation; acetylacja histonów; czerniak; epigenetics; epigenetyka; histone acetylation; melanoma; metylacja DNA

Discipline

• MEDICINE: MEDICINE

• Publisher: Śląski Uniwersytet Medyczny w Katowicach
• Journal: Annales Academiae Medicae Silesiensis
• Year: 2012
• Volume: 66
• Issue: 3
• Pages: 44–56

Contributors

author

Ewa Chodurek

• Katedra i Zakład Biofarmacji Wydziału Farmaceutycznego z Oddziałem Medycyny Laboratoryjnej Śląskiego Uniwersytetu Medycznego w Katowicach ul. Narcyzów 1 41-200 Sosnowiec tel. [phone]

author

Karolina Gołąbek

• Katedra i Zakład Biofarmacji Śląskiego Uniwersytetu Medycznego w Katowicach

author

Joanna Orchel

• Katedra i Zakład Biologii Molekularnej Wydziału Farmaceutycznego z Oddziałem Medycyny Laboratoryjnej Śląskiego Uniwersytetu Medycznego w Katowicach

author

Arkadiusz Orchel

• Katedra i Zakład Biofarmacji Śląskiego Uniwersytetu Medycznego w Katowicach

author

Zofia Dzierżewicz

• Katedra i Zakład Biofarmacji Śląskiego Uniwersytetu Medycznego w Katowicach

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• Document Type: article