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2014 | 17 | 2 | 69-74
Article title

Polimorfizmy w genach naprawy DNA a uszkodzenia indukowane przez ołów – analiza piśmiennictwa

Title variants
DNA repair genes polymorphisms and damages induced by lead – a literature review
Languages of publication
Lead is a toxic metal, which due to its superb properties
is used in many industries. Due to the wide spectrum of
its effects to human body it is very important to enhance
the knowledge on the mechanisms of lead’s toxicity as
well as to identify genetic determinants of defense against
the harmful effects. DNA repair is one of the most important
defense mechanisms against damage induced by
lead. Gene polymorphisms may influence the recovery
rate and recovery efficiency, and thus shape the individual
susceptibility to lead exposure.
Ołów to metal o toksycznym działaniu, który ze względu
na niezwykłe właściwości jest wykorzystywany w wielu
dziedzinach przemysłu. Jego szerokie spektrum działania
na organizm człowieka powoduje, że jest przedmiotem
licznych badań skupiających się na wyjaśnieniu
mechanizmów jego działania oraz identyfikacji genetycznych
wyznaczników obrony przed szkodliwym wpływem
tego metalu. Jednym z istotnych mechanizmów obrony
przed uszkodzeniami generowanymi przez ołów jest naprawa
DNA. Polimorfizmy w genach naprawczych mogą
wpływać na szybkość i efektywność naprawy, a zatem
kształtować wrażliwość osobniczą na ołów obecny w środowisku.

Physical description
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Publication order reference
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