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2018 | 101 | 229-236
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Acetylsalicylic acid in prevention of preeclampsia

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Preeclampsia is a frequent and dangerous complication of pregnancy. It is a significant cause of death for the mother and baby. In the course of this disease, the blood flow in the placenta is impaired, what leads to foetus hypoxia. It is characterized by high blood pressure and frequently large amount of protein in urine. To describe whether acetylsalicylic acid is effective in prevention of preeclampsia. Standard up-to-date criteria were followed for review of the literature data. A search for English-language articles in PubMed database was performed. Papers published in 2017 were reviewed. In double-blind trial published in 2017 in The New England Journal of Medicine researchers divided women who were at high risk for preeclampsia into two groups. One group was receiving acetylsalicylic acid and other was receiving placebo. Preeclampsia was observed in 1.6% participants in the acetylsalicylic acid group, compared with 4.3% in the placebo group. From other study we found out that acetylsalicylic acid has a dose-response effect. Greater reduction in the risk of preeclampsia was reported with the acetylsalicylic acid dosage >75 mg/d. When acetylsalicylic acid was included in treatment at >16 weeks, there was less reduction of preeclampsia without relationship with acetylsalicylic acid dosage. Other meta-analysis shows that there was no statistically significant difference in occurrence of preeclampsia between women who started taking acetylsalicylic acid before and after 16th week of pregnancy. Acetylsalicylic acid is a good agent to prevent of preeclampsia. It should be prescribed to women in high risk groups regardless of the duration of pregnancy even though it may not reduce the risk of preeclampsia as much as before 16th week of gestation.
Physical description
  • Student Research Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Poland
  • Student Research Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Poland
  • Student Research Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Poland
  • Student Research Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Poland
  • Department of Human Anatomy, Chair of Human Anatomy, Medical University of Lublin, Poland
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