MicroRNA and Immune Response to Viral, Bacterial and Fungal Infections

• Authors: Oluwafemi Ojo Agosile , Utibe Benson , Ugochukwu Oduwe , Nyerovwo Charity Okei , Sunday Joseph Fajobi , Sunday Onyedikachukwu Akachukwu , Bolaji Oyenike Oyetayo , Akinwale John Faniyi , Prisca Chinonso Njoku , Abolaji Samson Olagunju
• Languages of publication: EN

Abstracts

EN

Several kinds of microRNA have been studied as prospective biomarkers in the pursuit of better diagnostics tests for infectious diseases. miRNA which is processed mostly from introns plays a significant role in gene expression involving cell differentiation, proliferation, apoptosis, metabolism, and immune response. Many miRNA mimics or inhibitors are in their clinical phases and advancement in RNA interference will make miRNA become effective tools in the treatment of human infectious diseases. miRNA has been discovered to be largely involved in viral gene regulation as well as the change of host cellular genes during viral infections. The role of miRNA in most bacterial infections has not been thoroughly explored compared to viral infections. Recent studies have highlighted the vital role of host immunity against bacterial infections. miRNA that is sequenced due to fungal infections bear a close similarity to those produced in response to allergy or inflammation. Host-derived miRNA plays a vital role in immune regulation; inflammatory responses may be enhanced or inhibited by its upregulation or downregulation. Here, we outlined the involvement of microRNA in viral, fungal, and bacterial infections and the immune response associated. Further studies on these, will provide advanced diagnostic and treatment protocols for infectious diseases.

Keywords

EN

immune response; infectious disease; introns; miRNA; microRNA

Discipline

• BIOLOGY: BIOLOGY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2022
• Volume: 44
• Pages: 24-42

Contributors

author

Oluwafemi Ojo Agosile

• Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria

author

Utibe Benson

• Department of Medical Laboratory Science, Rivers State University, Port Harcourt, Rivers State, Nigeria

author

Ugochukwu Oduwe

• Department of Medical Laboratory Services, University of Benin Teaching Hospital, Benin-city, Edo State, Nigeria

author

Nyerovwo Charity Okei

• Department of Biological Sciences, University of Camerino, Camerino Macerata, Italy

author

Sunday Joseph Fajobi

• Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria

author

Sunday Onyedikachukwu Akachukwu

• Department of Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria

author

Bolaji Oyenike Oyetayo

• Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Oyo State, Nigeria

author

Akinwale John Faniyi

• Department of Medical Laboratory Science, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria

author

Prisca Chinonso Njoku

• Department of Biochemistry, University of Lagos, Lagos, Nigeria

author

Abolaji Samson Olagunju

• Department of Immunology, Institute of Biomedical Science, University of Sao Paulo, Brazil

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