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Journal
2019 | 9 | 4 | 92-95
Article title

Seizure as first manifestation of endocarditis in a patient with metastatic pancreatic adenocarcinoma: a case report

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EN
Abstracts
EN
Nonbacterial thrombotic endocarditis is a potentially overlooked condition that involves the formation of sterile fibrin vegetations on heart valve leaflets in cancer patients. This condition can lead to valvular dysfunction, heart failure and systemic embolization. The pathogenesis depends on hypercoagulable states which are common in malignancy scenarios. Diagnosis requires the presence of valvular vegetations and the absence of infection.
Discipline
Publisher

Journal
Year
Volume
9
Issue
4
Pages
92-95
Physical description
Contributors
  • Department of Cardio-Oncology of the Cancer Institute of São Paulo, University of São Paulo
  • Department of Cardio-Oncology of the Cancer Institute of São Paulo, University of São Paulo
  • Department of Cardio-Oncology of the Cancer Institute of São Paulo, University of São Paulo
  • 1. Department of Cardio-Oncology of the Cancer Institute of São Paulo, University of São Paulo. 2. Heart Institute of São Paulo, University of São Paulo
  • Department of Cardio-Oncology of the Cancer Institute of São Paulo, University of São Paulo
  • 1. Department of Cardio-Oncology of the Cancer Institute of São Paulo, University of São Paulo. 2. Heart Institute of São Paulo, University of São Paulo, ludhmila@usp.br
References
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  • 2. Liu J, Frishman WH. Nonbacterial Thrombotic Endocarditis: Pathogenesis, Diagnosis, and Management. Cardiol Rev. 2016; 24(5): 244-7.
  • 3. el-Shami K, Griffiths E, Streiff M. Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment. Oncologist. 2007; 12(5): 518-23.
  • 4. Seok JM, Kim SG, Kim JW et al. Coagulopathy and embolic signal in cancer patients with ischemic stroke. Ann Neurol. 2010; 68(2): 213-9.
  • 5. Deppisch LM, Fayemi AO. Non-bacterial thrombotic endocarditis: clinicopathologic correlations. Am Heart J. 1976; 92(6): 723-9.
  • 6. Sia CH, Lim JS, Poh KK et al. A classical case of non-bacterial thrombotic endocarditis from pancreatic adenocarcinoma presenting as multiple strokes, myocardial infarction and acute limb ischaemia. Oxf Med Case Reports. 2016; 2016(11): omw084.
  • 7. Goldenberg N, Kahn SR, Solymoss S. Markers of coagulation and angiogenesis in cancer-associated venous thromboembolism. J Clin Oncol. 2003; 21(22): 4194-9.
  • 8. Chen X, Chen SD, Dong Y et al. Patent foramen ovale closure for patients with cryptogenic stroke: A systematic review and comprehensive meta-analysis of 5 randomized controlled trials and 14 observational studies. CNS Neurosci Ther. 2018; 24(10): 853-62.
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  • 16. Patel MR, Mahaffey KW, Garg J et al; ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011; 365(10): 883-91.
  • 17. Giugliano RP, Ruff CT, Braunwald E et al; ENGAGE AF-TIMI 48 Investigators. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013; 369(22): 2093-104.
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Document Type
article
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Identifiers
YADDA identifier
bwmeta1.element.psjd-db91a122-518f-43d3-95a8-148160096c8d
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