PHYSICOCHEMICAL PROPERTIES OF GELS WITH CHITOSAN THAT PROTECT THE OESOPHAGEAL MUCOSA

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

The incidence of reflux disease increases with age, regardless of gender. This disease is diagnosed more often in highly developed countries. In addition to acidic reflux, the discharge of alkaline intestinal contents into the oesophagus is a major problem. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and hydroxypropylmethylcellulose on the properties of chitosan-containing gels. Preparations containing 4.0% hydroxypropylmethylcellulose showed the lowest pH. These gels could be used to treat advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of the hydroxypropylmethylcellulose concentration on the adhesion work of the tested gels.

Keywords

EN

antiinflammatory drugs; gastroesophageal alkaline reflux; hydrophilic gels; oesophageal infections; oesophageal mucosa; physiological environment of gastroesophageal

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Polish Chitin Society
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2022
• Volume: 27
• Pages: 175-182

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Wroclaw Medical University Department of Drug Form Technology, Faculty of Pharmacy The ‘Silesian Piasts’ Memorial Wroclaw Medical University

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• Document Type: article