Alteration of Cytomorphology of Peritoneal Macrophages of Albino Rat Exposed to Mercuric Compound
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Mercury is among the heavy metals that have been reported to cause devastating health problems worldwide. The present work was aimed at investigating the effects of mercury chloride on the cytomorphology of the peritoneal macrophages of rat. The current study characterizes the mechanism by which mercury, a toxic metal, induces death in rat macrophages. In mercury treated group significant numbers of peritoneal macrophages were found to be pyknotic. The cellular death was confirmed by membrane blebbing and membrane rupture. Percentages of cells showing membrane blebbing was increased significantly after treatment. The result indicated mercury induced toxicity may affect macrophage mediated immunity. So macrophage activation during heavy metal mediated reaction is an interesting area to be explored in future researches.
-  Abdel-Moneim, A.M and Abdel-Mohsen, H.A (2010). Ultrastructure changes in hepatocytes of catfish Clarias gariepinus from Lake Mariut. Egypt. J. Environ. Biol. 31: 715-720.
-  Buttke, T.M., Sandstrom, P.A (1994). Oxidative stress as a mediator of apoptosis. Immunol. Today 15: 7-10.
-  Christensen, M.M., Ellermann-Eriksen, S., Rungby, J., Mogensen, S.C (1996). Influence of mercuric chloride on resistance to generalized infection with herpes simplex virus type 2 in mice. Toxicology 114: 57-66.
-  Gregory, S.H., Wing, E.J (2002). Neutrophil –Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections. J. Leukocyte Biol. 72: 239- 248.
-  Guria, S., Das, M (2016). Cytoplasmic vacuolation in resident peritoneal macrophages in rat exposed to lead acetate: the apoptosis/necrosis/ paraptosis paradox. J. Atoms and Molecules., 6(1): 946-954.
-  Guria, S (2016). Enumeration and Structural Assessment of Murine Peritoneal Macrophages Exposed to Chromium (VI): A Preliminary Study. Journal of Global Biosciences 5(2): 3650-3655.
-  Guria, S., Chhetri, S., Saha, S., Chetri, N., Singh, G., Saha, P.B., Sarkar, B.S., Das, M (2012a). Study of cytomorphology of pancreatic islets and peritoneal macrophage in alloxan induced diabetic rat: a mechanistic insight. Animal Biology Journal 3(3): 101-110.
-  Guria, S and Das, M (2012). Phagocytosis of Yeast Particles by Peritoneal Macrophage in Normal and Hyperthyroid Rat. Animal Biology Journal 3(1): 51-57.
-  Guria, S., Chhetri, S., Saha, S., Chetri, N., Singh, G., Saha, P.B., Sarkar, B.S and Das, M (2012b). Pulmonary Involvement of Arsenic Poisoning and Effect of Arsenic Toxicity on Peritoneal Macrophages and Spleen Cells in Rat. Animal Biology Journal 3(2): 67-76.
-  Guria, S and Das, M (2011). Hypothyroidism reduces phagocytic activity of rat macrophage. Animal Biology Journal 2(4): 163-170.
-  Ibegbu, A.O., Micheal, A., Animoku Abdulrazaq, A., Daniel, B., Adamu Sadeeq, A., Peter, A., Hamman, W.O., Umana, U. E., Musa, S.A (2014). Effect of Ascorbic acid on Mercury-induced changes on the liver in Adult Wistar Rats. IOSR Journal of Dental and Medical Sciences., 13(10): 10-16.
-  InSug, O., Datar, S., Koch, C.J., Shapiro, I.M., Shenker, B.J (1997). Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology 124: 211-224.
-  Iyengar, U.R. and Vakil, U.K (1985). Enumeration and structural assessment of peritoneal macrophages during progressive protein deficiency in rats. J. Biosci. 7: 15-26.
-  Jiang, Y., Moller, G (1995). In vitro effects of HgCl2 on murine lymphocytes. Preferable activation of CD4+ T cells in a responder strain. J. Immunol. 154: 3138-3146.
-  Lucky, T.D (1987). Metal toxicity in mammals; New York Plenum Press. 20-28.
-  Morrissette, N., Gold, E., Aderem, A (1999). The macrophage—A cell for all seasons. Trends Cell Biol. 9: 199-201.
-  Ray, M., Bhunia, A.S., Bhunia, N.S., Ray, S (2013). Density shift, morphological damage, lysosomal fragility and apoptosis of hemocytes of Indian molluscs exposed to pyrethroid pesticides. Fish Shellfish Immunol. 35: 499-512.
-  Shenker, B.J., Rooney, C., Vitale, L., Shapiro, I.M. (1992). Immunotoxic effects of mercuric compounds on human lymphocytes and mono¬cytes. I. Suppression of T-cell activation. Immunopharmacol Immunotoxicol. 14(3): 539-553.
-  Woods, J.S., Dieguez-Acuna, F.J., Ellis, M.E., Kushleika, J., Simmonds, P.L (2002). Attenuation of nuclear factor kuppa B (NF-kuppa B) promotes apoptosis of kidney epithelial cells: a potential mechanism of mercury-induced nephrotoxicity. Environ. Health Perspect. 110: 819-822.
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