Evaluation of in vitro antidiabetic and antioxidant activities of different extracts of the root of Telfairia occidentalis Hook.fil. (Cucurbitaceae)

• Authors: Bright Jumbo , Olurunfemi A. Eseyin , Justice Chinedu Alozie
• Languages of publication: EN

Abstracts

EN

The leaves of Telfairia occidentalis are widely used as vegetable in the preparation of soups and consumed as food although it can also be used as an infusion in medicinal preparations due to its various medicinal properties such as anti-anemic, antidiabetic and antimicrobial activities etc. The present study sought to undertake the screening and quantification of the secondary metabolites and in vitro antioxidant and antidiabetic properties of the different extracts of the root of Telfairia occidentalis. Phytochemical constituents were determined using standard procedures. Antioxidant activity of the extracts was evaluated using DPPH scavenging activity and the antidiabetic activity evaluated using hemoglobin glycosylation and glucose uptake by yeast. The results of the phytochemical screening showed that the root of T. occidentalis contains saponins and alkaloids and quantitatively 4.7% and 1.26% respectively. From the antioxidant evaluation, the different extracts of the root of T. occidentalis were able to scavenge DPPH free radicals in a concentration dependent manner. The antidiabetic evaluation showed that the different extracts could inhibit hemoglobin glycosylation. The different extracts also caused an increase in glucose uptake by yeast than glibenclamide when compared together with Sample C (99.8% ethanol soxhlet extract) having the highest of these properties. In conclusion, the root of T. occidentalis can be employed in the treatment of diseases in which participation of reactive oxygen species are implicated such as diabetes.

Keywords

EN

Antidiabetic; Antioxidant; DPPH Activity; Hemoglobin Glycosylation; Telfairia occidentalis; Yeast Uptake

Discipline

• BIOCHEMISTRY: BIOCHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2025
• Volume: 58
• Pages: 28-43

Contributors

author

Bright Jumbo

• Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, AkwaIbom State, Nigeria

author

Olurunfemi A. Eseyin

• Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, AkwaIbom State, Nigeria

author

Justice Chinedu Alozie

• Department of Forestry and Wildlife Resource Management, Faculty of Agriculture Forestry and Wildlife Resource Management, University of Calabar, Cross River State, Nigeria

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• Document Type: article