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2019 | 119 | 231-237
Article title

Synthesis and characterization of novel 2-oxo-4-((4-(3-oxomorpholino)phenyl)amino)-2H-chromene-3-carbonitrile derivatives

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A highly functionalized heterocyclic library were synthesized, and characterized by common spectroscopic methods. This novel synthetic rout involves nucleophilic substitution reaction of 3-cyano-4chloro coumarin with 4-(4-aminophenyl)morpholin-3-one in the presence of base and methanol as a solvent in good yield and high purity. Key starting material 4-(4-aminophenyl)morpholin-3-one synthesized from aniline. The reaction of aniline with ethylene oxide gives INT-1 which on reaction with Chloroacetyl chloride yield INT-b. Nitration of INT-b gives INT-c, which on reduction with Sn/HCl gives int-D. Further INT-3 was synthesized from 4-hydroxy coumarin. The Vilsmeier-haack reaction of 4-hydroxy coumarin gives INT-01 which on reaction with hydroxylamine hydrochloride and sodium acetate furnished INT-03. All the synthesized compound of libraries characterized using 1H NMR, Mass, and IR spectroscopic technique.
Physical description
  • SMT. J.A. Patel Mahila College, Patel Kanya Chhatralaya Campus, B/H New bus station, Morbi - 363641, Gujarat, India
  • T.N. Rao College, Saurashtra University Campus, Rajkot - 360005, Gujarat, India
  • SMT. J.A. Patel Mahila College, Patel Kanya Chhatralaya Campus, B/H New bus station, Morbi - 363641, Gujarat, India
  • Shree H.N. Shukla College of Science, B/H Marketing yard, Bhichari, Rajkot, Gujarat, India
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