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2021 | 154 | 34-47
Article title

Modeling the Diffusion of Dichlorvos through Human Stomach Lining

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Abstracts
EN
Dichlorvos is the main poison in sniper pesticide which has produced negative effects especially among youths in recent times. The poisonous effects of dichlorvos on humans require urgent studies to combat the damaging impacts among humans. However, the limitations of carrying out experiments on human test subjects request the quest for alternative approach. Such approach can be made through modeling the transport of dichlorvos in the human body and the resulting negative effect. Therefore, this work presents mathematical modeling for the diffusion of dichlorvos through the human stomach lining. The model is set up to determine the amount of dichlorvos that leaves the stomach through diffusion alone and the health effects various concentration of the poison has on humans. Two cases are studied in order to captivate the effects of dichlorvos poisoning for two different scenarios. The initial condition is set to 0.05L and different driving forces is used to model the scenarios in spherical coordinates. The governing equation is derived from Fick’s first law and is solved analytically, a numerical solution is obtained using MATLAB’s pdepe solver and graphs are plotted for the two cases. From the results it is observed that about 14.4% of dichlorvos is diffused through the stomach lining in about 60hours for the first case while for the second case, the periodic intake of water along with dichlorvos gradually reduces the dichlorvos concentration in the stomach. These results show consistency with some experimental results from literature. Therefore, the model can be used in addition to the modes of treatment obtained from literature to predict the concentration of dichlorvos in a person and also proffer a life-saving treatment.
Discipline
Year
Volume
154
Pages
34-47
Physical description
Contributors
author
  • Department of Mechanical Engineering, University of Lagos, Lagos, Nigeria
  • Department of Mechanical Engineering, University of Lagos, Lagos, Nigeria
References
  • [1] Eddleston, M., Buckley, N. A., Eyer, P., & Dawson, A. H. Management of acute organophosphorus pesticide poisoning. The Lancet, 371(9612) (2018) 597-607
  • [2] Emerson, G. M., Gray, N. M., Jelinek, G. A., Mountain, D., & Mead, H. J. Organophosphate poisoning in perth, western australia, 1987–1996. The Journal of Emergency Medicine, 17(2) (1999) 273-277
  • [3] Ghosh, P., Cao, X., Pal, J., Chowdhury, S., Saha, S., Nandi, S., & Roy, P. K. Mathematical Modeling for the Prevention of Methanol Poisoning Through Ethanol by Impulsive Way. Differential Equations and Dynamical Systems, 1-18 (2018). https://doi.org/10.1007/s12591-018-0420-z
  • [4] Kora, S., A., Doddamani, G., B., Halagali, G., R., Vijayamahantesh, S., N., Boke, U. Sociodemographic profile of the organophosphorus poisoning cases in Southern India. Journal of Clinical and Diagnostic Research, 5(5) (2011) 953-956
  • [5] Musa, U., Hati, S. S., Mustapha, A., & Magaji, G. Dichlorvos concentrations in locally formulated pesticide (Ota-piapia) utilized in northeastern Nigeria. Scientific Research and Essays, 5(1) (2010) 049-054
  • [6] Ezeji EU, Ogueri OD, Udebuani AC, Okereke JN, Kalu OO. Effects of Dichlorvos on the fertility of adult male albino rats. Nature and Science 13(12) (2015) 1–5
  • [7] National Resarch Council. (1999). Risk Assessment of Radon in Drinking Water. Wahington, DC: The National Academies Press.
  • [8] Rapaccini, G. L., Aliotta, A., Pompili, M., Grattagliano, A., Anti, M.., Merlino, B., & Gambassi, G. (1988). Gastric wall thickness in normal and neoplastic subjects: a prospective study performed by abdominal ultrasound. Abdominal Imaging, 13(1) (1998) 197-199
  • [9] Olufemi, A. S., & Olayebi, O. O. Transportation Process of Alcohol in the Human Body System. Austin J Biomed Eng, 4(1) (2017) 1039
  • [10] ATSDR, (Agency for toxic substances and disease registry). Prepared by Clement International Corp., under contract, 205 (2000), 88-0608.
  • [11] Musa, U., Hati, S. S., Mustapha, A., & Magaji, G. Dichlorvos concentrations in locally formulated pesticide (Ota-piapia) utilized in northeastern Nigeria. Scientific Research and Essays, 5(1) (2010) 049-054
  • [12] Shimizu, K., Shiono, H., Fukushima, T., Sasaki, M., Akutsu, H., & Sakata, M. Tissue distribution of DDVP after fatal ingestion. Forensic Science International, 83(1) (1996) 61-66
  • [13] Shwe, D. D., Toma, B., Pate, S. I., Adedeji, I., & Oguche, S. Profile of hospital admissions of childhood poisoning at a North-Central Nigerian Tertiary Health Care Centre. Jos Journal of Medicine, 7(2) (2013) 5-11
  • [14] Singh, G., & Khurana, D. (2009). Neurology of acute organophosphate poisoning. Neurology India, 57(2), 119
  • [15] Cahfer G, Mustafa A, Murat O, Ismail HK. Dichlorvos poison after intramuscular injection. American Journal of Emergency Medicine 22(4) (2004) 328-330
  • [16] Celic I, Yilmaz Z, Turkoglu V. Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats. Environmental Toxicology 24(2) (2009) 128-132
  • [17] Das YT, Taskar PK, Brown HD, et al. Exposure of professional pest control operator to dichlorvos (DDVP) and residue on house structures. Toxicol Lett. 17(1–2) (1983) 95-99
  • [18] Ezeji EU, Ogueri OD, Udebuani AC, Okereke JN, Kalu OO. Effects of Dichlorvos on the fertility of adult male albino rats. Nature and Science 13 (12) (2015) 1-5
  • [19] Faris SK. Effects of dichlorvos pesticide on fertility of laboratory male mice (Mus musculus L.). Bas J Vet Res. 7(1) (2008) 9-18
  • [20] Hou Y, Zeng Y, Li S, Qi L, Xu W, Wang H, et al. Effects of quercetin against dichlorvos induced nephrotoxicity in rats. Experimental and Toxicologic Pathology 66(4) (2014) 211-218
  • [21] Lieberman MT, Alexander M. Microbial and nonenzymatic steps in the decomposition of Dichlorvos (2,2-Dichlorvinyl, O, O-Dimethyl phosphate). J Agric Food Chem. 31(2) (1983) 265-267
  • [22] Loeffler JE, Potter JC, Scordelis SL, et al. Long Term exposure of swine to a 14C dichlorvos atmosphere. J Agric Food Chem. 24(2) (1976) 367-371
  • [23] Mathias CG. Persistent contact dermatitis from the insecticide dichlorvos. Contact Derm. 9(3) (1983) 217-218
  • [24] Nazam N, Shaikh S. Assessment of genotoxic potential of the insecticide Dichlorvos using cytogenetic assay. Interdiscip Toxicol. 6(2) (2013) 76–82
  • [25] Romeo-Navarro G, Lopez Acevez T, Rojas-Ochoa A, Meja CF. Effects of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression, and on insulin MRNA levels. Life Sciences 78(9) (2006) 1015-1020
  • [26] Teichert-kuliszewska K, Szymczyk T. Change in rat carbohydrate metabolism after acute and chronic treatment with dichlorvos. Toxicol Appl Pharmacol. 47(2) (1979) 323–30.
  • [27] Varo I, Navarro JC, Amat F, Guilhermino L. Effects of dichlorvos on cholinesterase activity of the European sea bass (Dicentrarchus labrax. Pesticide Biochemistry and Physiology 75 (2003) 61-72
  • [28] Wang HH, Chou YC, Liao JF, Chen CF. The effect of the insecticide dichlorvos on esterase activity extracted from the psocids, Liposcelis bostrychophilaand L. Entomophilia J Insect Sci. 4 (2004) 1-5
  • [29] Wright AS, Hutson DH, Wooder MF. The chemical and biochemical reactivity of dichlorvos. Arch Toxicol. 42(1) (1979) 1-18
  • [30] Zhao SX, Zhang QS, Kong L, Zong YG, Wang RQ, Nan YM, et al. Dichlorvos induced autoimmune hepatitis: A case report and review of literature. Hepat Mon. 15(4) (2015), e25469
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-ce3da843-668b-4d54-a040-7d886c486754
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