THE EFFECT OF A POLYVINYL ALCOHOL AND DEXTRANE ON THE PROPERTIES OF THERMOSENSITIVE HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

Gels containing lactic acid complexed with chitosan at a stoichiometric ratio 1:1 and 2:1 and 5 - 25% content of polyoxyethylene glycol 200 reveal pH from 2.5 to 4.6. The addition of 20 – 25% poloxamer 407 increases the pH to 4.55 to 5.30 for 1:1 gels and 4.00 to 4.85 for 2:1 gels. The addition of 0.5% polyvinyl alcohol decreases the pH of the investigated gels to 4.00 to 4.55 for 1:1 gels and 3.85 to 4.40 for 2:1 gels. The addition of 1.0% dextrane decreases the pH of investigated gels to 4.40 to 4.90 (1:1) and 4.00 to 4.48 (2:1). Rheological investigations revealed an increase in the dynamic viscosity of preparations containing poloxamer 407 with the addition of polyvinyl alcohol or dextrane in comparison to the reference gels. Results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.

Keywords

EN

anti-inflammatory drugs.; dextrane; lactic acid complexed with chitosan; polyvinyl alcohol; thermosensitive polymer - poloxamer 407; vaginal infections

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2011
• Volume: 16
• Pages: 99 - 104

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw

References

• Schwebke J. R.; (2009) New Concepts in the Etiology of Bacterial Vaginosis. Curr. Infect. Dis. Rep. Vol. 11, pp. 143-147.
• Brandt M., Abels C., May T., Lohmann K., Schmidts – Winkler I., Hoyme U. B.; (2008) Intravaginally applied metronidazole is as effective as orally applied in the treatment of bacterial vaginosis, but exhibits significantly less side effects. Eur. J. Obstet. Gynecol. Reprod. Biol. Vol. 141, pp. 158-162.
• Donders G. G. G., Larson P. G., Platz-Christensen J. J., Hallen A., Meijden W., Wölner-Hanssen P.; (2009) Variability in diagnosis of clue cells, lactobacillary grading and white blood cells in vaginal wet smears with conventional bright light and phase contrast microscopy. Eur. J. Obstet. Gynecol. Reprod. Biol. Vol. 145, pp. 109-112.
• Kubis A. A., Małolepsza-Jarmołowska K.; (1996) Studies on gynecological hydrophiling preparations comprising lactic acid. Part 1: Effects of lactic acid and hydrophiling agents on physical and chemical properties of methylcellulose gels. Pharmazie Vol. 51, pp. 989-990.
• Małolepsza-Jarmołowska K,, Kubis A. A.; (1999) Studies on gynecological hydrophilic lactic acid preparations. Part 2: Effects of Eudragit® E-100 on properties of methylcellulose gels. Pharmazie Vol. 54, pp. 441-443.
• Małolepsza-Jarmołowska K., Kubis A. A.; (2000) Studies on gynaecological hydrophilic lactic acid preparations. Part 3: Effects of chitosan on the properties of methylcellulose gels. Pharmazie Vol. 55, pp. 610-611.
• Małolepsza-Jarmołowska K., Kubis A. A.; (2001) Studies on gynaecological hydrophilic lactic acid preparations. Part 4: Effects of polyvinyl pyrrolidone K-90 on properties of methylcellulose gels. Pharmazie Vol. 56, pp. 160-162.
• Małolepsza-Jarmołowska K., Kubis A. A., Hirnle L.; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 5: The use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie Vol. 58, pp. 260-262.
• Małolepsza-Jarmołowska K., Kubis A. A., Hirnle L.; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 6: Use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie Vol. 58, pp. 334-336.
• Małolepsza-Jarmołowska K.; (2006) Studies on gynaecological hydrophilic lactic acid preparations. Part 7: Use of chitosan as lactic acid carrier in intravaginal tablets (globuli vaginales). Pharmazie Vol. 61, pp. 780 - 782.
• Małolepsza-Jarmołowska K.; (2007) Studies on gynaecological hydrophilic lactic acid preparations. Part 8: Use of chitosan as lactic acid carrier in intravaginal tablets. Acta Pol. Pharm. Vol. 64, pp. 69-72.
• Małolepsza-Jarmołowska K.; (2010) The effect of poloxamer 407 on the properties of hydrophilic gels containing lactic acid complexed with chitosan. Progress on Chemistry and Application of Chitin and Its Derivatives, Vol. XV pp. 143-148.

• Document Type: article