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2010 | 15 | 117 - 126
Article title

ANALYSIS OF MODEL DRUG RELEASE KINETICS FROM COMPLEX MATRICES OF POLYLACTIDE-CHITOSAN

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EN
Abstracts
EN
In the present paper the Authors analyse the experimental results of a model drug (ibuprofen) release approximated with three commonly used semi-empirical models: Korsmeyer-Peppas, first order kinetics and Gallagher-Corrigan equation. Drug carriers in the form of films composed of chitosan matrix and polylactide microparticles were produced by ultrasonic emulsification with solvent evaporation followed by film casting technique. Additionally, polylactide shield layers (5μm thick) were attached to both sides of obtained films by means of spray-coating process. A microscopic analysis confirmed the uniform distribution of polylactide microparticles (diameter: 1-2 μm) within chitosan films. Based on the of microscopic study, molecular drug dispersion within composite matrices was found. Fraction of ibuprofen released into medium of pH equal to 1.4 or 7.2 (GI tract) was measured by means of UV-VIS spectrophotometry. The finest approximation was obtained by fitting two-stage release model derived by K. M. Gallagher and O. I. Corrigan to the release data. Analysis of model parameters led to the conclusion that the increase of composite films thickness as well as weight fraction of PLA microparticles within films prolong drug release.
Publisher

Year
Volume
15
Pages
117 - 126
Physical description
Contributors
  • Faculty of Process and Environmental Engineering, Technical University of Lodz, ul. Wolczanska 213, 90-924, Lodz, Poland, jacek.balcerzak@gmail.com
author
  • Faculty of Process and Environmental Engineering, Technical University of Lodz, ul. Wolczanska 213, 90-924, Lodz, Poland
References
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  • Siepmann J., Gopferich A.; Mathematical modeling of bioerodible, polymeric drug delivery systems, Adv. Drug. Delivery Rev. 48 (2001) pp. 229-247.
  • Gallagher K. M., Corrigan O. I.; Mechanistic aspects of the release of levamisole hydrochloride from biodegradable polymers, J. Contr. Release 69 (2000) pp. 261-272.
  • O’Donnell P. B., McGinity J. W.; Preparation of microspheres by the solvent evaporation technique, Adv. Drug Delivery Rev. 28 (1997) pp. 25-42.
  • Balcerzak J., Mucha M.; PLA microgranules used as carriers of active substances prepared by emulsification in chitosan solution, Progress on Chemistry and Application of Chitin and Its Derivatives vol. XIV (2009) pp. 101-110 (www.ptchit.lodz.pl)
  • Trimaille T., Pichot C., Elaissari A., Fessi H., Briancon S., Delair T.; Poly(D,L-lactic acid) Nanoparticle Preparation and Colloidal Characterization. Colloid Polym. Sci. 281 (2003) pp. 1184-1190.
  • Wang C., Ye W., Zheng Y., Liu X., Tong Z.; Fabrication of drug-loaded biodegradable microcapsules for controlled release by combination of solvent evaporation and layer-by-layer selfassembly. Int. J. Pharm. 338 (2007) pp. 165-173.
  • Proikakis C. S., Tarantili P. A., Andreopoulos A.G.; The role of polymer/drug interactions on the sustained release from poly (DL-lactic acid) tablets, Eur. Polym. J. 42 (2006) pp. 3269-3276.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-caa5ed2c-3a07-4782-8bd1-66c3bb13223a
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