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Number of results
2012 | 25 | 99 | 41-46

Article title

Rola wolnych rodników w regulacji procesów fizjologicznych.

Content

Title variants

EN
Role of free radicals in physiological processes

Languages of publication

PL

Abstracts

EN
Free radicals containing one or more unpaired electrons have considerable reactivity. Those radicals derived from oxygen represent the most important class of such species. Free radicals generated in organism are reactive oxygen species (ROS) and reactive nitrogen species (RNS) well recognised for playing a dual role as both deleterious and beneficial species. The cumulative production of ROS/RNS is termed oxidative stress and were discovered in pathomechanism of many of diseases. It was observed that in medium concentration ROS and RNS are play a role in inflammation, apoptosis and as secondary messengers in intracellular signalling cascades.

Year

Volume

25

Issue

99

Pages

41-46

Physical description

Contributors

  • Zakład Radioligandów, Katedra Farmakobiologii, Wydział Farmaceutyczny, Uniwersytet Jagielloński Collegium Medicum, ul. Medyczna 9, 30-688 Kraków
  • Zakład Radioligandów, Katedra Farmakobiologii, Wydział Farmaceutyczny, Uniwersytet Jagielloński Collegium Medicum, ul. Medyczna 9, 30-688 Kraków
author
  • Zakład Bromatologii, Wydział Farmaceutyczny, Uniwersytet Jagielloński Collegium Medicum, ul. Medyczna 9, 30-688 Kraków
  • Zakład Chemii Nieorganicznej, Katedra Chemii Nieorganicznej i Analitycznej, Wydział Farmaceutyczny Uniwersytet Jagielloński Collegium Medicum, ul. Medyczna 9, 30-688 Kraków

References

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  • De Minicis S., Bataller R., Brenner D.A. 2006. NADPH Oxidase in the Liver: Defensive, Offensive, or Fibrogenic? Gastroenterology, 131, 272-275.
  • Dröge W. Free Radicals in the Physiological Control of Cell Function. 2002. Physiological Reviews 82, 47-95.
  • Fialkov L., Wang Y., Downey G.P. 2007. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radical Biology & Medicine 42, 153-164.
  • Fleury C., Mignotte B, Vayssière J-L. 2002. Mitochon-drial reactive oxygen species in cell death signaling. Biochimie 84, 131–141.
  • Geiszt M. 2006. NADPH oxidases: New kids on the block. Cardiovascular Research 71, 289-299.
  • Genestra M. 2007 Oxyl radicals, redox-sensitive signlling cascades and antioxidants. Cellular Signaling 19, 1807-1819.
  • Hultqvist M., Olsson L.M., Gelderman K.A., Holdahl R. 2009. The protective role of ROS in autoimmune disease. Trends in Immunology 30, 201-208.
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  • Lance B. Becker. 2004. New concepts in reactive oxygen species and cardiovascular reperfusion physiology Cardiovascular Research 61, 461– 470.
  • Rauhala P., Andoh T., Chiueh C.C. 2005. Neuroprotective properties of nitric oxide and S nitrosoglutathione Toxicology and Applied Pharma-cology 207, S91 – S95.
  • Simon H.-U., Haj-Yehia A., Levi-Schaffer F. 2000. Role of reactive oxygen species (ROS) in apoptosis induc-tion. Apoptosis 5, 415-418.
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  • Valko M., Leibfritz D., Moncol J., Cronin M.T.D., Mazur M., Telser J. 2007. Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry & Cell Biology 39, 44–84.
  • Zorov D. B. , Bannikova S. Y., Belousov V.V., Vyssokikh M. Y., Zorova L. D., Isaev N. K., Krasnikov B. F., and Plotnikov E. Y. 2005. Reactive Oxygen and Nitrogen Species: Friends or Foes? Biochemistry (Moscow), 70, 215-221.
  • Rovira I.I and Finkel T. 2008. Reactive Oxygen, Nitro-gen, And Thiol-Based Signal Transduction. In: Redox Biochemistry, edited by Ruma Banerjee. John Wiley & Sons, Inc.
  • Hultqvist M., Olsson L.M., Gelderman K.A., and Holmdahl R. 2009.The protective role of ROS in auto-immune disease. Trends in Immunology 30, 201-208.
  • Starkov A.A. 2008. The Role of Mitochondria in Reac-tive Oxygen Species Metabolism and Signaling. Annals of the New York Academy of Sciences 1147, 37–52.
  • Bao X., Cui J., Wu Y., Han X., Gao C., Hua Z. , Shen P. 2007. The roles of endogenous reactive oxygen species and nitric oxide in triptolide-induced apoptotic cell death in macrophages. Journal of Molecular Medicine 85, 85–98
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Document Type

article

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.psjd-ca5e961d-90ef-4d31-8c1c-66f840d6b4da
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