PL EN


Preferences help
enabled [disable] Abstract
Number of results
2018 | 100 | 154-164
Article title

Spectrum of gluten-related disorders: celiac disease, wheat allergy, baker’s asthma and non-celiac gluten sensitivity

Content
Title variants
Languages of publication
EN
Abstracts
EN
Gluten, which is a protein found in wheat, can trigger some gastrointestinal diseases in people with genetic predisposition. Gluten related disorders include celiac disease (CD), wheat allergy, baker’s asthma and non-celiac gluten sensivity (NCGS). Approximately 1% of population suffers from celiac disease. It is believed, that the occurrence of the disease is determined by the interaction of genetic, immunological and environmental factors. The consequence of the inflammatory process is the atrophy of the intestinal villi. That results in impaired bowel motility, improper digestion and impaired absorption of substances contained in the diet. Wheat allergy occurs among people with a genetic predisposition to allergies. People with this disorder are sensitized to products containing gluten and every contact with this antigen leads to mast cell activation and the release of mediators of the allergic reaction - mainly histamine. They mainly affect the skin (urticaria, atopic eczema, angioedema), digestive system (nausea, vomiting, spasmic abdominal pain) and respiratory tract (asthma, allergic rhinitis). Baker’s asthma is an interesting and common allergic, occupational disorder related to inhalation of flour containing gluten. The main symptoms include: conjunctivitis, rhinitis, dermatitis, as well as work-related cough and dyspnea. First reports on non-celiac gluten sensitivity (NCGS) appeared in 1980. The diagnosis of non-celiac gluten sensitivity is based on the exclusion of celiac disease and food allergy in a patient who has symptoms induced by ingestion of gluten. The exact pathomechanism of this disease is still unknown. Interestingly, some researches doubt that this disorder is caused by gluten intake. All of the above-mentioned diseases have a similar spectrum of clinical symptoms, and as part of the treatment require an elimination diet with the exclusion of gluten. The aim of this study is to provide information on gluten-related diseases, taking into account their pathomechanism and clinical picture.
Discipline
Year
Volume
100
Pages
154-164
Physical description
Contributors
  • Faculty of Medicine, Wroclaw Medical University, 5 J. Mikulicza-Radeckiego Str., 50-345 Wroclaw, Poland
  • Faculty of Medicine, Wroclaw Medical University, 5 J. Mikulicza-Radeckiego Str., 50-345 Wroclaw, Poland
  • Faculty of Medicine, Wroclaw Medical University, 5 J. Mikulicza-Radeckiego Str., 50-345 Wroclaw, Poland
  • Department of Gastroenterology and Hepatology, Wroclaw Medical University, 213 Borowska Str., 50-556 Wroclaw, Poland
author
  • Department of Gastroenterology and Hepatology, Wroclaw Medical University, 213 Borowska Str., 50-556 Wroclaw, Poland
References
  • [1] Tanpowpong P, Ingham TR, Lampshire PK, et al. Coeliac disease and gluten avoidance in New Zealand children. Arch Dis Child (2012) 97(1): 12–16.
  • [2] Tanpowpong P, Broder-Fingert S, Katz AJ, Camargo CA. Predictors of Gluten Avoidance and Implementation of a Gluten-Free Diet in Children and Adolescents without Confirmed Celiac Disease. J Pediatr (2012) 161(3): 471–475.
  • [3] Choung RS, Unalp-Arida A, Ruhl CE, Brantner TL, Everhart JE, Murray JA. Less Hidden Celiac Disease But Increased Gluten Avoidance Without a Diagnosis in the United States. Mayo Clin. Proc (2017) 92(1): 30–38.
  • [4] Valenti S, Corica D, Ricciardi L, Romano C. Gluten-related disorders: certainties, questions and doubts. Ann Med (2017) 49(7): 569–581.
  • [5] Biesiekierski JR. What is gluten? J Gastroenterol Hepatol (2017) 32: 78–81.
  • [6] Heredia-Sandoval NG, Valencia-Tapia MY, Calderón de la Barca AM, Islas-Rubio AR. Microbial Proteases in Baked Goods: Modification of Gluten and Effects on Immunogenicity and Product Quality. Foods (Basel, Switzerland) (2016) 5(3).
  • [7] Gujral N, Freeman HJ, Thomson ABR. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J. Gastroenterol (2012) 18(42): 6036–59.
  • [8] Catassi C, Gatti S, Fasano A. The New Epidemiology of Celiac Disease. J. Pediatr Gastroenterol Nutr (2014) 59: S7–S9.
  • [9] Parzanese I, Qehajaj D, Patrinicola F, Aralica M, Chiriva-Internati M, Stifter S, Elli L, Grizzi F. Celiac disease: From pathophysiology to treatment. World J. Gastrointest Pathophysiol (2017) 8(2):27–38.
  • [10] Peña AS. Immunogenetics of non celiac gluten sensitivity. Gastroenterol Hepatol Bed Bench (2014) 7(1): 1–5.
  • [11] Pallav K, Kabbani T, Tariq S, Vanga R, Kelly CP, Leffler DA. Clinical utility of celiac disease-associated HLA testing. Dig Dis Sci (2014) 59(9): 2199–206.
  • [12] Caja S, Mäki M, Kaukinen K, Lindfors K. Antibodies in celiac disease: implications beyond diagnostics. Cell Mol Immunol (2011) 8(2): 103–9.
  • [13] Hojsak I, Shamir R. Tissue transglutaminase antibodies in celiac disease: focus on the pediatric population. Drugs of Today (2011) 47(9): 683.
  • [14] Tollefsen S, Arentz-Hansen H, Fleckenstein B, Molberg O, Raki M, Kwok WW, Jung G, Lundin KE, Sollid LM. HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. J. Clin. Invest. (2006) 116(8): 2226–36.
  • [15] Greco L, Romino R, Coto I, Di Cosmo N, Percopo S, Maglio M, Paparo F, Gasperi V, Limongelli MG, Cotichini R, Stazi MA. The first large population based twin study of coeliac disease. Gut, (2002) 50(5): 624–8.
  • [16] Lebwohl B, Ludvigsson JF, Green PHR. Celiac disease and non-celiac gluten sensitivity. BMJ, (2015) 351: 4347.
  • [17] Thompson T. Wheat Starch, Gliadin, and the Gluten-free Diet. J Am Diet Assoc (2001) 101(12): 1456–1459.
  • [18] Comino I, Moreno ML, Sousa C. Role of oats in celiac disease. World J. Gastroenterol (2015) 21(41): 11825–31.
  • [19] Pinto-Sánchez MI et al. Gluten Introduction to Infant Feeding and Risk of Celiac Disease: Systematic Review and Meta-Analysis. J. Pediatr (2016) 168: 132–143.
  • [20] Silano M, Agostoni C, Guandalini S. Effect of the timing of gluten introduction on the development of celiac disease. World J. Gastroenterol. (2010) 16(16): 1939–42.
  • [21] Szajewska H, Shamir R, Mearin L, Ribes-Koninck C, Catassi C, et al. Gluten Introduction and the Risk of Coeliac Disease. J Pediatr Gastroenterol Nutr (2016) 62(3): 507–513.
  • [22] Gray AM, Papanicolas IN. Impact of symptoms on quality of life before and after diagnosis of coeliac disease: results from a UK population survey. BMC Health Serv. Res (2010) 10: 105.
  • [23] Rubio-Tapia A, Murray JA. Celiac disease. Curr. Opin. Gastroenterol., (2010) 26(2): 116–22.
  • [24] Schuppan D, Zimmer KP. The diagnosis and treatment of celiac disease. Dtsch. Arztebl. Int (2013) 110(49): 835–46.
  • [25] Kaswala DH, Veeraraghavan G, Kelly CP, Leffler DA. Celiac Disease: Diagnostic Standards and Dilemmas. Dis. (Basel, Switzerland) (2015) 3(2): 86–101.
  • [26] Shomaf M, Rashid M, Faydi D, Halawa A. Is the Diagnosis of Celiac Disease Possible Without Intestinal Biopsy? Balkan Med. J. (2017) 34(4): 313–317.
  • [27] Mazzarella G. Effector and suppressor T cells in celiac disease. World J. Gastroenterol (2015) 21(24): 7349–56.
  • [28] Reeves GE, Burns C, Hall ST, Gleeson M, Lemmert K, Clancy RL. The measurement of IgA and IgG transglutaminase antibodies in celiac disease: a comparison with current diagnostic methods. Pathology (2000) 32(3): 181–5.
  • [29] Lau MS, Mooney PD, White WL, Rees MA, Wong SH, Kurien M, Trott N, Leffler DA, Hadjivassiliou M, Sanders DS. The Role of an IgA/IgG-Deamidated Gliadin Peptide Point-of-Care Test in Predicting Persistent Villous Atrophy in Patients With Celiac Disease on a Gluten-Free Diet. Am. J. Gastroenterol. (2017) 112(12): 1859–1867.
  • [30] Bürgin-Wolff A, Berger R, Gaze H, Huber H, Lentze MJ, Nusslé D. IgG, IgA and IgE gliadin antibody determinations as screening test for untreated coeliac disease in children, a multicentre study. Eur. J. Pediatr. (1989) 148(6): 496–502.
  • [31] Zevit N, Shamir R. Diagnosis of Celiac Disease. J. Pediatr Gastroenterol Nutr (2014) 59: S13–S15.
  • [32] Grossman G. Neurological complications of coeliac disease: what is the evidence? Pract. Neurol. (2008) 8(2): 77–89.
  • [33] Goddard CJR, Gillett HR. Complications of coeliac disease: are all patients at risk?, Postgrad. Med. J. (2006) 82(973): 705–12.
  • [34] Inomata N. Wheat allergy. Curr. Opin. Allergy Clin. Immunol., (2009) 9(3): 238–243.
  • [35] Guandalini S, Newland C. Differentiating Food Allergies from Food Intolerances. Curr. Gastroenterol. Rep. (2011) 13(5): 426–434.
  • [36] Cianferoni A. Wheat allergy: diagnosis and management. J Asthma Allergy (2016) 9: 13–25.
  • [37] Battais F, Richard C, Szustakowski G, Denery-Papini S, Moneret-Vautrin DA, Leduc V, Guerin L. Wheat flour allergy: an entire diagnostic tool for complex allergy. Eur Ann Allergy Clin. Immunol (2006) 38(2): 59–61.
  • [38] Czaja-Bulsa G, Bulsa M. What Do We Know Now about IgE-Mediated Wheat Allergy in Children? Nutrients (2017) 9(1).
  • [39] Anagnostou K, Meyer R, Fox A, Shah N. The rapidly changing world of food allergy in children. F1000Prime Rep (2015) 7: 35.
  • [40] Irani AM, Akl EG. Management and Prevention of Anaphylaxis. F1000Research (2015) 4.
  • [41] Elli L, Branchi F, Tomba C, Vilalta D, Norsa L, Ferretti F, Roncoroni L, Bardella MT. Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity. World J Gastroenterol (2015) 21(23): 7110–9.
  • [42] Salvatori N, Reccardini F, Convento M, Purinan A, Colle R, De Carli S, Garzoni M, Lafiandra D, De Carli M. Asthma induced by inhalation of flour in adults with food allergy to wheat. Clin Exp Allergy (2008) 38(8):1349–1356.
  • [43] Brisman J. Baker’s asthma. Occup Environ Med. (2002) 59(7): 498-502.
  • [44] Stobnicka A, Górny RL. Exposure to flour dust in the occupational environment. Int J Occup Saf Ergon (2015) 21(3): 241–9.
  • [45] Weichel M, Glaser AG, Ballmer-Weber BK, Schmid-Grendelmeier P, Crameri P. Wheat and maize thioredoxins: A novel cross-reactive cereal allergen family related to baker’s asthma. J Allergy Clin Immunol (2006) 117(3): 676–681.
  • [46] Sander I, Flagge A, Merget R, Halder TM, Meyer HE, Baur X. Identification of wheat flour allergens by means of 2-dimensional immunoblotting. J Allergy Clin Immunol (2001) 107(5): 907–913.
  • [47] Salcedo G, Quirce S, Diaz-Perales A. Wheat allergens associated with Baker’s asthma. J. Investig Allergol Clin Immunol (2011) 21(2): 81–92.
  • [48] Lummus ZL, Wisnewski AV, Bernstein DI. Pathogenesis and Disease Mechanisms of Occupational Asthma. Immunol Allergy Clin North Am (2011) 31(4): 699–716.
  • [49] Page EH, Dowell CH, Mueller CA, Biagini RE, Heederik D. Exposure to flour dust and sensitization among bakery employees. Am J Ind Med (2010) 53(12): 1225–1232.
  • [50] Lemière C. When to suspect occupational asthma. Can. Respir. J. (2013) 20(6): 442–4.
  • [51] Bachanek T, Chalas R, Pawlowicz A, Tarezydto B. Exposure to flour dust and the level of abrasion of hard tooth tissues among the workers of flour mills. Ann Agric Environ Med (1999) 6(2): 147–9.
  • [52] Cooper BT, Holmes GK, Ferguson R, Thompson RA, Allan RN, Cooke WT. Gluten-sensitive diarrhea without evidence of celiac disease. Gastroenterology, (1980) 79(5): 801–806.
  • [53] Leonard MM, Sapone A, Catassi C, Fasano A. Celiac Disease and Nonceliac Gluten Sensitivity. JAMA (2017) 318(7): 647.
  • [54] Vasagar B, Cox J, Herion JT, Ivanoff E. World epidemiology of non-celiac gluten sensitivity. Minerva Gastroenterol Dietol (2017) 63(1): 5–15.
  • [55] Mansueto P, Seidita A, D’Alcamo A, Carroccio A. Non-Celiac Gluten Sensitivity: Literature Review. J. Am. Coll. Nutr. (2014) 33(1): 39–54.
  • [56] Watkins RD, Zawahir S. Celiac Disease and Nonceliac Gluten Sensitivity. Pediatr. Clin. North Am (2017) 64(3): 563–576.
  • [57] Igbinedion SO, Ansari J, Vasikaran A, Gavins FN, Jordan P, Boktor M, Alexander JS. Non-celiac gluten sensitivity: All wheat attack is not celiac. World J. Gastroenterol (2017) 23(40): 7201–7210.
  • [58] Biesiekierski JR, Iven J. Non-coeliac gluten sensitivity: piecing the puzzle together. United Eur Gastroenterol J (2015) 3(2): 160–5.
  • [59] De Giorgio R, Volta U, Gibson PR. Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction? Gut (2016) 65(1): 169–178.
  • [60] Makharia A, Catassi C, Makharia GK. The Overlap between Irritable Bowel Syndrome and Non-Celiac Gluten Sensitivity: A Clinical Dilemma. Nutrients (2015) 7(12): 10417–26.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-c981d1f5-856d-46a9-ae83-434fbf85c22d
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.