PHARMACEUTICAL ASSESSMENT OF THERMOSENSITIVE HYDROPHILIC GELS WITH POLYVINYL PYRROLIDONE K-30 CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5-25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm.
Measurements performed in a biopharmaceutical model revealed that the addition of 20% poloxamer 407 to gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 decreases their movability from 20 to 25 cm and at 2:1 ratio, from 22 to 28 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 20 to 24 cm.
The addition of 5% PVP K-30 besides 1,2-propylene glycol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 24 cm to 28 cm and at 2:1 ratio from 26 cm to 30 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 24 to 27 cm

Keywords

EN

1; 2- propylene glycol; glycerol; lactic acid complexed with chitosan; polyvinyl pyrrolidone K-30; thermosensitive polymer - poloxamer 407; vaginal infections

Discipline

• MEDICINE: MEDICINE

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2013
• Volume: 18
• Issue: 18
• Pages: 123-131

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Faculty of Pharmacy, "Silesian Piast" memorial Medical University of Wroclaw

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• Document Type: article