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2013 | 18 | 18 | 123-131
Article title

PHARMACEUTICAL ASSESSMENT OF THERMOSENSITIVE HYDROPHILIC GELS WITH POLYVINYL PYRROLIDONE K-30 CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

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EN
Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5-25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm.
Measurements performed in a biopharmaceutical model revealed that the addition of 20% poloxamer 407 to gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 decreases their movability from 20 to 25 cm and at 2:1 ratio, from 22 to 28 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 20 to 24 cm.
The addition of 5% PVP K-30 besides 1,2-propylene glycol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 24 cm to 28 cm and at 2:1 ratio from 26 cm to 30 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 24 to 27 cm
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18
Issue
18
Pages
123-131
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References
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article
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bwmeta1.element.psjd-c7387137-adce-4d55-8b5a-4279a6310c8d
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