Investigating the antibacterial and antifungal properties of few organic moieties: a comprehensive analysis

• Authors: S. Nisha , M. Saravanan , K. K. Ilavenil
• Languages of publication: EN

Abstracts

EN

The existing work reveals the novel character of organic compounds like 4-Methoxyphenoxyacetic acid and p-dihydroxybenzene. The compounds were investigated for their antibacterial and antifungal prospective against gram-positive bacteria. At increasing doses of 2-Methoxyphenoxyacetic acid, the zone of inhibition for Salmonella paratyphi was (30 mm/ml) at 100 µl and p-dihydroxybenzene is more resistant to bacterial such as Bacillus subtilis (38 mm/ml), Enterococcus faecalis (40 mm/ml), Mucor (42 mm/ml), Aspergillus niger (40 mm/ml). The docking investigation was carried out using Auto Dock 4.2.6; interactions between hydrogen atoms and the smallest ligands with macromolecules had the lowest binding energies.

Keywords

EN

4-Methoxyphenoxyacetic acid; auto dock; binding energy; biological activity; p-dihydroxybenzene; zone of inhibition

Discipline

• BIOLOGY: BIOLOGY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2023
• Volume: 50
• Pages: 33-41

Contributors

author

S. Nisha

• Department of Chemistry, Nehru Memorial College, Affiliated to Bharathidasan University, Puthanampatti, Tiruchirappalli - 621007, Tamil Nadu, India

author

M. Saravanan

• Department of Chemistry, Nehru Memorial College, Affiliated to Bharathidasan University, Puthanampatti, Tiruchirappalli - 621007, Tamil Nadu, India

author

K. K. Ilavenil

• Department of Chemistry, Nehru Memorial College, Affiliated to Bharathidasan University, Puthanampatti, Tiruchirappalli - 621007, Tamil Nadu, India

References

• [1] McFadyen, M.C.E., Melvin, W.T., & Murray, G.I. (2004). Cytochrome P450 enzymes: novel options for cancer therapeutics. Molecular Cancer Therapy, 3 (3), 363-371
• [2] Starcevic, K., Caleta, I., Cincic, D., Kaitner, B., Kralj, M., Ester, K., & Karminski-Zamola, G. (2006). Synthesis, crystal structure determination and antiproliferative evaluation of novel benzazoyl benzamides. Heterocycles, 68 (11), 2243-2246
• [3] Katsuura, K. (1985). Directed ortho metalation reactions. Synthesis of the naturally-occurring benz [a]anthraquinones X-14881 C and ochromycinone. Tetrahedron Letters, 26 (1), 9-12
• [4] Anbarasu, K., & Ilavenil, K. K. (2017). Kinetics of Oxidation of few organic substrates by chromium (VI) compounds – A Review, International Journal of ChemTech Research, 10 (7), 341-349
• [5] Anbarasu, K., & Ilavenil, K. K. (2018). Synthesis, Characterization and Pharmacological Activity of Phenoxy Acetic Acid and Pyrazinium Chlorochromate. Asian Journal of Chemistry, 30(10), 2238-2240. https://doi.org/p10.14233/ajchem.2018.21417
• [6] Ilavenil, K. K., Pandian, P., Kasthuri, A., & Senthilkumar, V. (2021). Structural Activities of Derivatives of Phenol. Annals of Romanian Society of Cell Biology, 25 (6), 17257-17269
• [7] Ilavenil, K. K., Anusha, R., Senthil Kumar, V., & Anbarasu, K. (2021). Reactivity of Phenoxy Acetic Acid and Oxidation Kinetics Using Pyrazinium Chlorochromate, Annals of Romanian Society of Cell Biology, 25 (6), 17352-17363
• [8] Anbarasu, K., & Ilavenil, K. K. (2018). Oxidation of Phenol by Pyrazinium Chlorochromate. Journal of Emerging Technologies and Innovative Research, 5 (11), 167-171
• [9] Ilavenil, K. K., Kasthuri, A., & Anbarasu, K. (2022). Oxidation kinetics of Phenol, its derivatives and some para-substituted phenol by Pyrazinium chlorochromate in acidic medium: A Non-Linear Hammett Plots, Rasayan Journal of Chemistry, 15 (3), 1660-1667. http://doi.org/10.31788/RJC.2022.1536920
• [10] Srinivasan, D., & Ilavenil, K. K. (2017). Biosorption of heavy metals and dyes using plant weeds - A review. International Journal of ChemTech Research, 10 (7), 1038-1047.
• [11] Srinivasan, D., & Ilavenil, K. K. (2017). Bioremediation of dyes and heavy metal ions using cynodon dactylon. A review. Journal of Chemical and Pharmaceutical Sciences, 10 (1), 363-370
• [12] Ilavenil, K. K., Pandian, P., & Kasthuri, A. (2023). Adsorption study of removal of lead ions using Prosopis juliflora and prediction by artificial neural network modelling, Materials Today Proceedings, 72, 2344-2350. https://doi.org/10.1016/j.matpr.2022.09.402
• [13] Senthilkumar Vagheesan and Jayaprakash Govindarajulu. (2021). Comparative Regression and Neural Network Modeling of Roughness and Kerf Width in CO2 Laser Cutting of Aluminium. Tehnički Vjesnik, 28 (5), 1437-1441. https://doi.org/10.17559/TV-20190130153849
• [14] Karthikeyan, R., Senthilkumar, V., Thilak, M., & Nagadeepan, A. (2018). Application of Grey Relational Analysis for Optimization of Kerf quality during CO2 laser cutting of Mild Steel. Materials Today: Proceedings, 5 (9), 19209-19215. https://doi.org/10.1016/j.matpr.2018.06.276
• [15] Vagheesan, S., Govindarajalu, J. Hybrid neural network–particle swarm optimization algorithm and neural network–genetic algorithm for the optimization of quality characteristics during CO2 laser cutting of aluminium alloy. J Braz. Soc. Mech. Sci. Eng. 41, 328 (2019). https://doi.org/10.1007/s40430-019-1830-8
• [16] Senthilkumar, V., Periyasamy, N., & Manigandan, A. (2015). Parametric investigation of process parameters for laser cutting process. International Journal of Innovative Research in Science, Engineering and Technology, 4(5), 2773–2779
• [17] Anbarasu, K., & Ilavenil, K. K. (2019). Structural activity of unsaturated alcohols and oxidation towards pyrazinium chlorochromate, Oriental Journal of Chemistry, 35 (1), 436-441. http://dx.doi.org/10.13005/ojc/350156
• [18] Senthilkumar, V., & Ilavenil, K. K. (2023). Artificial Neural Network Prediction of Optimal Phenylic Acid Adsorption using Lantana camara Activated Carbon, Oriental Journal of Chemistry, 39 (1), 172-178. http://dx.doi.org/10.13005/ojc/390121
• [19] Senthilkumaran, R., & Pavithra, E. (2014). In-vitro sensitivity of bacterial and fungal pathogens to Datura alba - antimicrobial approaches. International Journal of Advanced Research in Biological Sciences, 1(1), 101-110. https://ijarbs.com/pdfcopy/apr2014/ijarbs10.pdf
• [20] Kunsch, C., Luchoomun, J., Chen, X. L., Dodd, G. L., Karu, K. S., Meng, C. Q., Marino, E. M., Olliff, L. K., Piper, J. D., Qiu, F. H., & Sikorski, J. A. (2005). AGIX-4207 [2-[4-[1-[3,5-bis (1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl) phenoxy] acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression. Journal of Pharmacology and Experimental Therapeutics, 313(2), 492-501. https://doi.org/10.1124/jpet.104.080804.
• [21] Yar, M.S., Siddiqui, A.A., & Ali, M.A. (2007). Oxadiazole mannich bases: Synthesis and antimycobacterial activity. Bioorganic & Medicinal Chemistry Letters, 14, 4571-4574. https://doi.org/10.1016/j.bmcl.2007.04.004
• [22] Meanwell, N.A., Rosenfeld, M.J., Kim Wright, J.J., Brassard, C.L., Buchanan, J.O., Federici, M.E., & Seiler, S.M. (1993). Nonprostanoid prostacyclin mimetics. 4. Derivatives of 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid substituted alpha. to the oxazole ring. Journal of Medicinal Chemistry, 36 (24), 3871-3883. https://doi.org/10.1021/jm00076a017
• [23] Ilavenil, K. K., & Dhamodharan, M. (2016). Synthesis, structure and characterization of Cr(III) and Fe(III) complex of m-nitro benzaldehyde thio semicarbazone, Journal of Chemical and Pharmaceutical Sciences, 9 (3), 1458-1462
• [24] Bhavna, S., Pravin P., & Hirva, S. (2014). Chemical modification of paracetamol and their antimicrobial and pharmacological evaluation. International Research Journal of Pharmaceutical and Biosciences, 3, 12-31. https://innovareacademics.in/journals/index.php/ijpps/article/download/5005/7389/0
• [25] Turan-Zitouni, G., Yurttas, L., Kaplancıklı, Z. A. (2015). Synthesis and antinociceptive, anti-inflammatory activities of new aroyl propionic acid derivatives including N-acylhydrazone motif. Medicinal Chemistry Research, 24, 2406–16. https://doi.org/10.1007/s00044-014-1309-1
• [26] Koelsch, C. F. (1931). The Identification of Phenols. Journal of American Chemical Society, 53 (1), 304-305. https://doi.org/10.1021/ja01352a042

• Document Type: article