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2017 | 15 | 3 | 218–223
Article title

Trabektedyna w leczeniu raka jajnika

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Title variants
EN
Trabectedin for the treatment of ovarian cancer
Languages of publication
PL EN
Abstracts
EN
The paper describes standard therapeutic management used in patients with ovarian cancer, which is based, among other things, on the recommendations of the Polish Gynecological Oncology Society. Therapeutic management encompasses surgical treatment and systemic therapy with cytostatic drugs (typically derivatives of platinum and paclitaxel as first-line therapy). Total or optimal cytoreduction is an important element of surgical treatment. Additionally, the response to first-line adjuvant chemotherapy is a highly significant prognostic factor. Bevacizumab is an effective treatment in the first-line chemotherapy and in patients with platinum-sensitive relapsed ovarian cancer. Trabectedin (Yondelis) used in patients with relapsed ovarian cancer (partially platinum-sensitive) (relapse within 6–12 months after first-line chemotherapy) proved to be an effective drug. Used in combination with pegylated liposomal doxorubicin, the drug significantly improved progressionfree survival (time to progression ranging between 9.2 vs. 7.2 months, p = 0.017) as compared to pegylated liposomal doxorubicin alone. Improvement of overall survival was also demonstrated (22.4 vs. 18.9 months, p = 0.835), however, it was insignificant. In addition, trabectedin used in relapsed ovarian cancer increased sensitivity to platinum and exhibited low toxicity.
PL
W pracy opisano postępowanie terapeutyczne standardowo stosowane u chorych na raka jajnika, oparte m.in. na rekomendacjach Polskiego Towarzystwa Ginekologii Onkologicznej. Terapia obejmuje postępowanie operacyjne i systemowe leczenie cytostatykami (standardowo: pochodnymi platyny i paklitakselu w pierwszej linii leczenia). Istotnym elementem leczenia operacyjnego jest całkowita, ewentualnie optymalna cytoredukcja. Również odpowiedź na pierwszą linię adiuwantowej chemioterapii stanowi ważny czynnik prognostyczny. Podawanie bewacyzumabu w pierwszej linii leczenia chemicznego i w platynowrażliwym nawrotowym raku jajnika jest skutecznym sposobem terapii. U pacjentek ze wznową (w czasie 6–12 miesięcy po pierwszej linii chemioterapii) raka jajnika – częściowo platynowrażliwego – skutecznym lekiem okazała się trabektedyna (Yondelis). Stosowana z pegylowaną liposomalną doksorubicyną, wydłużyła znamiennie czas wolny od progresji (9,2 vs 7,2 miesięca, p = 0,017) w stosunku do stosowanej wyłącznie liposomalnej doksorubicyny. Wykazano też wydłużenie całkowitego przeżycia (22,4 vs 18,9 miesiąca, p = 0,835), choć statystycznie różnica nie była znamienna. Zaletami trabektedyny stosowanej we wznowie raka jajnika są zwiększenie wrażliwości guza na preparaty platyny oraz niska toksyczność.
Discipline
Publisher

Year
Volume
15
Issue
3
Pages
218–223
Physical description
Contributors
  • Klinika Onkologii, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Poznań, Polska, jmarkmed@poczta.onet.pl
  • Klinika Ginekologii Onkologicznej, Centrum Onkologii – Instytut im. Marii Skłodowskiej-Curie w Warszawie, Warszawa, Polska
author
  • Klinika Ginekologii Onkologicznej, Centrum Onkologii – Instytut im. Marii Skłodowskiej-Curie w Krakowie, Kraków, Polska
author
  • I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny w Lublinie, Lublin, Polska
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Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-c556dfbc-ec95-4c8a-b5fe-be790e03ac34
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