INCREASING THE EFFECTIVENESS OF CHITOSAN GELS TO PROTECT THE OESOPHAGEAL MUCOSA

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

The troublesome symptoms of gastro-oesophageal reflux disease are a serious health, medical, and social problem for patients. The main problem is gastro-oesophageal acid reflux. In this study, I investigated hydrogels that could prevent the destruction of the oesophageal mucosa. I investigated the effect of chitosan and poloxamer 407 on the protective properties of gels. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity. Preparations containing 25% poloxamer 407 showed the highest pH. Texture tests showed the effect of the poloxamer concentration on the adhesion performance of the tested gels. The findings suggest that the gels can be used to treat advanced acid reflux.

Keywords

EN

acid gastro-oesophageal reflux; anti-inflammatory drugs; hydrophilic gels; oesophageal infections; oesophageal mucosa; physiological gastro-oesophageal environment

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Polish Chitin Society
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2023
• Volume: 28
• Pages: 111-118

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Department of Drug Form Technology, Faculty of Pharmacy, The ‘Silesian Piasts’ Memorial Wroclaw Medical University, Borowska 211A Str., 50–556 Wrocław, Poland

References

• [1] Sasankan P, Thota PN; (2022) Evaluation and for the diagnosis and management of gastroesophageal reflux disease: A brief look at the updated guidelines. Clevel Clin J Med 89 (12), 700–703. DOI:10.3949/ccjm.89a.22059
• [2] Katz PO, Gerson LB, Vela MF; (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 108, 308–328. DOI:10.1038/ajg.2012.444
• [3] Raban M, Żak A, Litak J, Turska M, Grochowski C; (2017) Gastroesophageal reflux disease – unit description, diagnosis and treatment. J Educ Health Sport 7, 215–225. DOI:10.5281/zenodo.825357
• [4] Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus Group; (2006) The Montreal definition and classification of gastroesophageal reflux disease: a global evidence–based consensus. Am J Gastroenterol 101, 1900–1920. DOI:10.1111/j.1572–0241.2006.00630.x
• [5] Numans ME, Lau J, de Wit NJ, Bonis PA; (2004) Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Ann Intern Med 7, 518–527. DOI:10.7326/0003–4819–140–7-200404060–00011
• [6] Singh M, Lee J, Gupta N, Gaddam S, Smith BK, Wani SB; (2013) Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. Obesity 21, 284–290. DOI:10.1002/oby.20279
• [7] Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CAJ; (2006) Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 354, 2340–2348. DOI:10.1056/NEJMoa054391
• [8] Ze EY, Kim BJ, Kang H, Kim JG; (2017) Abdominal visceral to subcutaneous adipose tissue ratio is associated with increased risk of erosive esophagitis. Dig Dis Sci 62, 1265–1271. DOI:10.1007/s10620–017–4467–4
• [9] Gao F, Gao Y, Chen X, Qian J, Zhang J; (2017) Comparison of oesophageal function tests between Chinese non-erosive reflux disease and reflux hypersensitivity patients. BMC Gastroenterol 67, 1–7. DOI:10.1186/s12876–017–0624–7
• [10] Małolepsza-Jarmołowska K; (2019) Influence of chitosan on the properties of gels protecting of the esophageal mucosa Prog Chem Appl Chitin Deriv 24, 135–144. DOI:10.15259/PCACD.24.012

• Document Type: article