Malondialdehyde (MDA) – product of lipid peroxidation as marker of homeostasis disorders and aging

• Authors: Beata Całyniuk , Elżbieta Grochowska-Niedworok , Katarzyna W. Walkiewicz , Sylwia Kawecka , Ewa Popiołek , Edyta Fatyga

Title variants

PL

Dialdehyd malonowy – produkt peroksydacji lipidów jako marker zaburzeń homeostazy i wieku

• Languages of publication: EN

Abstracts

EN

Malondialdehyde (MDA) found in the body comes from two sources: food consumed and lipid peroxidation occurring in the tissues. The formation of MDA and the scale and rate of lipid oxidation in the tissues of living organisms is influenced by a number of endo- and exogeneous factors. The products of lipid peroxidation, in particular MDA, exhibit cytotoxic, mutagenic and carcinogenic properties. They can also inhibit enzymes associated with defending cells against oxidative stress. Not only do the occurring processes contribute to the development of many diseases, but they are also a part of the aging process. The body defends itself to some extent against the effects of free radicals by trapping and neutralising them. The main source of antioxidants is food products of plant origin. Lifestyle, the components of which are diet and physical activity, is an important element in preserving health understood as physical and psychological well-being. Dietary habits and a diet rich in antioxidants are modifiable factors which not only prevent age-associated diseases, but also delay aging processes.

PL

Dialdehyd malonowy (MDA) w organizmie człowieka pochodzi z dwóch źródeł: spożywanego pokarmu i peroksydacji lipidów występujących w tkankach. Powstawanie MDA, a także wielkość i szybkość utleniania lipidów w tkankach organizmów żywych, zależy od wielu czynników endo- i egzogennych. Produkty peroksydacji lipidów, szczególnie MDA, wykazują właściwości cytotoksyczne, mutagenne i rakotwórcze. Mogą one również hamować enzymy związane z obroną komórki przed stresem oksydacyjnym. Mogą nie tylko przyczyniać się do rozwoju wielu chorób, ale stanowią również część procesu starzenia się. Organizm broni się w pewnym stopniu przed działaniem wolnych rodników, neutralizując je. Głównym źródłem przeciwutleniaczy jest żywność – produkty pochodzenia roślinnego. Styl życia, na który składają się dieta i aktywność fizyczna, jest ważnym elementem w zachowaniu zdrowia rozumianego jako dobre samopoczucie fizyczne i psychiczne. Nawyki żywieniowe i dieta bogata w przeciwutleniacze są modyfikowalnymi czynnikami, które nie tylko zapobiegają chorobom związanym z wiekiem, ale także opóźniają procesy starzenia.

Keywords

EN

aging; free radicals; lifestyle; starzenie; styl życia; wolne rodniki tlenowe

Discipline

• MEDICINE: MEDICINE

• Journal: Annales Academiae Medicae Silesiensis
• Year: 2016
• Volume: 70
• Pages: 224–228

Contributors

author

Beata Całyniuk

• Department of Human Nutrition, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland

author

Elżbieta Grochowska-Niedworok

• Department of Human Nutrition, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland

author

Katarzyna W. Walkiewicz

• Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland, ul. Piekarska 18, 41-902 Bytom, tel. [phone],

author

Sylwia Kawecka

• Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland

author

Ewa Popiołek

• Department of Human Nutrition, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland

author

Edyta Fatyga

• Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland

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• Document Type: article