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2016 | 70 | 224–228
Article title

Malondialdehyde (MDA) – product of lipid peroxidation as marker of homeostasis disorders and aging

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Title variants
PL
Dialdehyd malonowy – produkt peroksydacji lipidów jako marker zaburzeń homeostazy i wieku
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EN
Abstracts
EN
Malondialdehyde (MDA) found in the body comes from two sources: food consumed and lipid peroxidation occurring in the tissues. The formation of MDA and the scale and rate of lipid oxidation in the tissues of living organisms is influenced by a number of endo- and exogeneous factors. The products of lipid peroxidation, in particular MDA, exhibit cytotoxic, mutagenic and carcinogenic properties. They can also inhibit enzymes associated with defending cells against oxidative stress. Not only do the occurring processes contribute to the development of many diseases, but they are also a part of the aging process. The body defends itself to some extent against the effects of free radicals by trapping and neutralising them. The main source of antioxidants is food products of plant origin. Lifestyle, the components of which are diet and physical activity, is an important element in preserving health understood as physical and psychological well-being. Dietary habits and a diet rich in antioxidants are modifiable factors which not only prevent age-associated diseases, but also delay aging processes.
PL
Dialdehyd malonowy (MDA) w organizmie człowieka pochodzi z dwóch źródeł: spożywanego pokarmu i peroksydacji lipidów występujących w tkankach. Powstawanie MDA, a także wielkość i szybkość utleniania lipidów w tkankach organizmów żywych, zależy od wielu czynników endo- i egzogennych. Produkty peroksydacji lipidów, szczególnie MDA, wykazują właściwości cytotoksyczne, mutagenne i rakotwórcze. Mogą one również hamować enzymy związane z obroną komórki przed stresem oksydacyjnym. Mogą nie tylko przyczyniać się do rozwoju wielu chorób, ale stanowią również część procesu starzenia się. Organizm broni się w pewnym stopniu przed działaniem wolnych rodników, neutralizując je. Głównym źródłem przeciwutleniaczy jest żywność – produkty pochodzenia roślinnego. Styl życia, na który składają się dieta i aktywność fizyczna, jest ważnym elementem w zachowaniu zdrowia rozumianego jako dobre samopoczucie fizyczne i psychiczne. Nawyki żywieniowe i dieta bogata w przeciwutleniacze są modyfikowalnymi czynnikami, które nie tylko zapobiegają chorobom związanym z wiekiem, ale także opóźniają procesy starzenia.
Discipline
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Year
Volume
70
Pages
224–228
Physical description
Contributors
  • Department of Human Nutrition, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland
  • Department of Human Nutrition, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland
  • Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland, ul. Piekarska 18, 41-902 Bytom, tel. 32 281 21 22, kk.walkiewicz@gmail.com
  • Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland
author
  • Department of Human Nutrition, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland
author
  • Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland
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Document Type
article
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YADDA identifier
bwmeta1.element.psjd-c487101f-1e4d-4976-9928-cd13216cc350
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