SYNTHESIS OF NEW CHITOSAN-CARBONATE HYDROXYAPATITE COMPOSITES WITH POTENTIAL APPLICATION IN BONE TISSUE ENGINEERING – PHYSICOCHEMICAL ANALYSIS

• Authors: Justyna Urbaniak , Barbara Kołodziejska , Agnieszka Kaflak
• Languages of publication: EN

Abstracts

EN

The subject of this study was the synthesis of 12 chitosan-hydroxyapatite (CH:HA) composites with different contents of carbonate ions (CO3 2-), in two weight ratios of CH to HA (30:70 and 50:50), and two viscosities of CH (low [L] and high [H]). The method of direct co-precipitation of the introduced reagents was used. The structure of the obtained materials was characterised by Fourier-transform infrared (FT-IR) spectroscopy, powder X-ray diffraction, and scanning electron microscopy. The FT-IR spectra revealed the bands and ranges of the characteristic bands for CH and HA. The presence of CO3 2- introduced into the structure of the obtained composites was identified by infrared spectroscopy. A reduction in the size of HA unit cells was observed in the obtained CH:HA biocomposites, in materials with a higher content of incorporated CO3 2-. The obtained nanomaterials are similar to natural bone tissue. Future research will focus on the evaluation of the obtained materials as a drug delivery system.

Keywords

EN

FT-IR; PXRD; biocomposite CH:HA; bone tissue; chitosan; hydroxyapatite

Discipline

• MEDICAL_BIOLOGY: MEDICAL BIOLOGY

• Publisher: Polish Chitin Society
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2022
• Volume: 27
• Pages: 217-227

Contributors

author

Justyna Urbaniak

• Student scientific group ‘Spectrum’ Medical University of Warsaw

author

Barbara Kołodziejska

• Department of Analytical Chemistry and Biomaterials, Medical University of Warsaw,

author

Agnieszka Kaflak

• Department of Analytical Chemistry and Biomaterials, Analytical Group, Medical University of Warsaw

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• Document Type: article