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2015 | 20 | 246-253
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This study aims to obtain nanoparticles based on succinoyl chitosan loaded with Warnerin (War-SCNPs), low molecular weight cationic peptide. The nanoparticles of succinoyl chitosan (SCNPs) were prepared by salt coacervation method, and Warnerin loading efficiency on SCNPs was reached 75% in the optimum conditions, particularly, ration (SCNPs : peptide) was equal to (1.75 : 1, μg / ml ). Formed War-SCNPs were stable, had a weak electric charge from (-4.4) to (-14,6) mV. Determining of SCNPs size showed that a main fraction of SCNPs had the size of 160 nm, and after the peptide sorption War-SCNPs size increased up to 330 nm. The experimental data of this study will likely impact War-SCNPs use as therapeutic delivery systems of the peptide to be administered parenteral.

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  • Centre «Bioengineering» RAS, Prospect 60-letiya Oktyabrya 7/1, Moscow, Russia,
  • Centre «Bioengineering» RAS, Prospect 60-letiya Oktyabrya 7/1, Moscow, Russia
  • Centre «Bioengineering» RAS, Prospect 60-letiya Oktyabrya 7/1, Moscow, Russia
  • Institute of Ecology and Genetics of Microorganisms, Ural Division of the RAS, Goleva 13, Perm, Russia
  • Institute of Ecology and Genetics of Microorganisms, Ural Division of the RAS, Goleva 13, Perm, Russia
  • Centre «Bioengineering» RAS, Prospect 60-letiya Oktyabrya 7/1, Moscow, Russia
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