FORMATION AND CHARACTERIZATION OF SUCCINOYL CHITOSAN PARTICLES LOADED WITH WARNERIN

• Authors: Balzhima Ts Shagdarova , Alla V. Ilyina , Sergey A. Lopatin , Vladimir P. Korobov , Larisa M. Lemkina , Valery P. Varlamov
• Languages of publication: EN

Abstracts

EN

This study aims to obtain nanoparticles based on succinoyl chitosan loaded with Warnerin (War-SCNPs), low molecular weight cationic peptide. The nanoparticles of succinoyl chitosan (SCNPs) were prepared by salt coacervation method, and Warnerin loading efficiency on SCNPs was reached 75% in the optimum conditions, particularly, ration (SCNPs : peptide) was equal to (1.75 : 1, μg / ml ). Formed War-SCNPs were stable, had a weak electric charge from (-4.4) to (-14,6) mV. Determining of SCNPs size showed that a main fraction of SCNPs had the size of 160 nm, and after the peptide sorption War-SCNPs size increased up to 330 nm. The experimental data of this study will likely impact War-SCNPs use as therapeutic delivery systems of the peptide to be administered parenteral.

Keywords

EN

chitosan nanoparticles   coacervation method   succinoyl chitosan   warnerin  

• Publisher: Polish Chitin Society
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2015
• Volume: 20
• Pages: 246-253

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• Document Type: article