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2018 | 18 | 2 | 72-78
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Synthesis, Characterization, In-Vitro Antimicrobial Evaluation and Antioxidant Studies of Some Isoxazoline Derivatives

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Tremendous rise in development of resistance to the antimicrobials has created alarming situation for researchers and clinicians. In this regard, an attempt has been made to develop a series of azole. The present study comprises of design and synthesis of some newer derivatives by incorporating isoxazole nucleus in the pharmacophore and characterizing them physicochemically and by spectral means. The synthesized compounds were structurally characterized on the basis of IR and microanalyses. All of the newly isolated compounds were tested for their antimicrobial activities. The antimicrobial screening using the agar disc diffusion method revealed that the most of the derivatives are the most active. Moreover, the antioxidant activity of these derivatives are also studied using the DPPH radical scavenging methods.

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  • Department of Chemistry, Annai College of Arts and Science, Kovilacheri, Kumbakonam, Tamil Nadu, India
  • Department of Chemistry, Annai College of Arts and Science, Kovilacheri, Kumbakonam, Tamil Nadu, India
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