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A series of N,O-acylated chitosan derivatives were emulsified with different fatty acids. Hydrophobically modified chitosan derivatives were expected to exhibit self-assembly behaviour resulting in micelle formation. Several parameters of the oil-in-water emulsification process were investigated: mixing method, speed and duration, volume oil phase and addition of modifiers. Their influence on micellar Z-average diameter, size distribution and Zeta potential was analysed based on dynamic light scattering measurements. There were various relations between the hydrodynamic behaviour of chitosan derivatives, their chemical structure and the process parameters. Additionally, the obtained micelles could serve as active compound carriers because they encapsulated two model substances, namely ibuprofen and α-tocopherol.






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  • Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology,
  • Faculty of Mechanical Engineering and Mechatronics, West Pomeranian University of Technology,
  • Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology,


  • T. Kean, M. Thanou, “Biodegradation, biodistribution and toxicity of chitosan,” Adv. Drug Deliv. Rev. vol.62 pp.3–11 2010. https://doi.org/10.1016/j.addr.2009.09.004.
  • S. Kwon, J.H. Park, H. Chung, I. C. Kwon, S.Y. Jeong, I.S. Kim, “Physicochemical Characteristics of Self-Assembled Nanoparticles Based on Glycol Chitosan Bearing 5β-Cholanic Acid,” Langmuir. vol.19 pp.10188–10193 2003. https://doi.org/10.1021/la0350608.
  • K.Y. Lee, W.H. Jo, I.C. Kwon, Y.H. Kim, S.Y. Jeong, “Physicochemical characteristics of self-aggregates of hydrophobically modified chitosans,” Langmuir. vol.14 pp.2329–2332 1998. https://doi.org/10.1021/la970928d.
  • Z. Wu, K. Xu, J. Min, M. Chen, L. Shen, J. Xu, Q. Jiang, G. Han, L. Pan, H. Li, “Folate-conjugated hydrophobicity modified glycol chitosan nanoparticles for targeted delivery of methotrexate in rheumatoid arthritis,” J. Appl. Biomater. Funct. Mater. vol.18 2020. https://doi.org/10.1177/2280800020962629.
  • A. Niemczyk, A. Kmieciak, M. El Fray, A. Piegat, “The influence of C18-fatty acids on chemical structure of chitosan derivatives and their thermal properties,” Prog. Chem. Appl. Chitin Its Deriv. vol.21 pp.165–175 2016. https://doi.org/10.15259/PCACD.21.18.
  • A. Niemczyk, A. Goszczyńska, M. Gołda-Cępa, A. Kotarba, P. Sobolewski, M. El Fray, “Biofunctional catheter coatings based on chitosan-fatty acids derivatives,” Carbohydr. Polym. vol.225 pp.115263 2019. https://doi.org/10.1016/j.carbpol.2019.115263.
  • S. Javadian, J. Kakemam, “Intermicellar interaction in surfactant solutions; a review study,” J. Mol. Liq. vol.242 pp.115–128 2017. https://doi.org/10.1016/j.molliq.2017.06.117.
  • J. Desbrieres, C. Bousquet, V. Babak, “Surfactant-chitosan interactions and application to emulsion stabilization,” Cellul. Chem. Technol. vol.44 pp.395–406 2010.
  • W. Li, H. Peng, F. Ning, L. Yao, M. Luo, Q. Zhao, X. Zhu, H. Xiong, “Amphiphilic chitosan derivative-based core-shell micelles: Synthesis, characterisation and properties for sustained release of Vitamin D3,” Food Chem. vol.152 pp.307–315 2014. https://doi.org/10.1016/j.foodchem.2013.11.147.
  • X. Zhu, D. Zhou, Y. Jin, Y. Song, Z. Zhang, Y. Huang, “A novel microsphere with a three-layer structure for duodenum-specific drug delivery.,” Int. J. Pharm. vol.413 pp.110–8 2011. https://doi.org/10.1016/j.ijpharm.2011.04.036.
  • A. Rodríguez, M. Del Mar Graciani, M. Muñoz, I. Robina, M.L. Moyá, “Effects of ethylene glycol addition on the aggregation and micellar growth of gemini surfactants,” Langmuir. vol.22 pp.9519–9525 2006. https://doi.org/10.1021/la062225e.
  • M.R.H. Rosdi, M.A. Ahmad Razali, K.M. Ku Ishak, A. Ariffin, “The Impact of Ethylene Glycol on Droplet Growth Inhibition in Ethylene Vinyl Acetate Emulsions,” ACS Omega. vol.5 pp.14473–14480 2020. https://doi.org/10.1021/acsomega.0c01114.
  • C. Carnero Ruiz, J.A. Molina-Bolívar, J. Aguiar, G. MacIsaac, S. Moroze, R. Palepu, “Effect of ethylene glycol on the thermodynamic and micellar properties of Tween 20,” Colloid Polym. Sci. vol.281 pp.531–541 2003. https://doi.org/10.1007/s00396-002-0801-1.
  • W. Fan, W. Yan, Z. Xu, H. Ni, “Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique,” Colloids Surfaces B Biointerfaces. vol.90 pp.21–27 2012. https://doi.org/10.1016/j.colsurfb.2011.09.042.
  • J.M. Park, S.Y. Lee, G.H. Lee, E.Y. Chung, K.M. Chang, B.K. Kwak, H.J. Kuh, J. Lee, “Design and characterisation of doxorubicin-releasing chitosan microspheres for anti-cancer chemoembolisation,” J. Microencapsul. vol.29 pp.695–705 2012. https://doi.org/10.3109/02652048.2012.686526.
  • T.V. Nguyen, T.T.H. Nguyen, S.-L. Wang, T.P.K. Vo, A.D. Nguyen, “Preparation of chitosan nanoparticles by TPP ionic gelation combined with spray drying, and the antibacterial activity of chitosan nanoparticles and a chitosan nanoparticle–amoxicillin complex,” Res. Chem. Intermed. 2016. https://doi.org/10.1007/s11164-016-2428-8.
  • M.S. Aw, M. Kurian, D. Losic, “Polymeric micelles for multidrug delivery and combination therapy,” Chem. - A Eur. J. vol.19 pp.12586–12601 2013. https://doi.org/10.1002/chem.201302097.
  • S. Deng, M.R. Gigliobianco, R. Censi, P. Di Martino, “Polymeric nanocapsules as nanotechnological alternative for drug delivery system: Current status, challenges and opportunities,” Nanomaterials. vol.10 2020. https://doi.org/10.3390/nano10050847.
  • A.K. dos S. Pereira, D.T. Reis, K.M. Barbosa, G.N. Scheidt, L.S. da Costa, L.S.S. Santos, “Antibacterial effects and ibuprofen release potential using chitosan microspheres loaded with silver nanoparticles,” Carbohydr. Res. vol.488 pp.107891 2020. https://doi.org/10.1016/j.carres.2019.107891.
  • H. Rehage, I. Wunderlich, H. Hoffmann, Shear induced phase transitions in dilute aqueous surfactant solutions, in: Polym. as Colloid Syst. Prog. Colloid Polym. Sci., Springer, 1986: pp. 51–59. https://doi.org/10.1007/bfb0114478

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