EN
2-Amino-4-(2’-n-butyl-4’-chloro-1’-H-imidazol-5’-yl)-6-aryl nicotinonitriles. (2a-2j); 2-Methoxy-4-(2’-n-butyl-4’-chloro-1’-H-imidazol-5’-yl)-6-aryl nicotinonitriles. (3a-3j) have been synthesized. The products have been assayed for their antimicrobial activity against Gram +ve bacteria and Gram –ve bacteria and fungi. The products have been characterized by IR, 1HNMR, Mass Spectra and TLC.