CHITOSAN ADDUCT WITH TRANEXAMIC ACID AND ITS HAEMOSTATIC EFFECT

• Authors: Volodymyr Antonyuk , Nazar Manko , Lidiia Panchak , Semen Khomyak , Rostyslav Stoika
• Languages of publication: EN

Abstracts

EN

Chitosan is a cationic polymer capable of binding acidic drugs. In addition, it has haemostatic and antimicrobial activity. Chitosan derivatives withanti-fibrinolytic properties may present increased effectiveness, especially when the added substance forms an adduct with chitosan. The aim of this work was to study the haemostatic action of the chitosan–tranexamic acid complex. Two chitosan solutions (molecularweight of 250 and 625 kDa at pH 5.7 and 6.2, and after tranexamic acid had been added to chitosan solutions) werestudied. Haemostatic evaluation was performed on white outbred mice. The time to complete cessation of bleeding from the tail was determined. Chitosan 625 kDa at pH 6.2 had the best haemostatic properties. Adding tranexamic acid to the chitosan solution reduced the bleeding time. This phenomenon was more pronounced for chitosan 625 kDa. Compared with control animals, this chitosan reduced bleeding arrest time by 30% and the chitosan–tranexamic acid adduct reduced the bleeding arrest time by 75%.

Keywords

EN

adduct; chitosan; tranexamic acid; haemostatic effect

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Polish Chitin Society
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2022
• Volume: 27
• Pages: 35-42

Contributors

author

Volodymyr Antonyuk

• Danylo Halytsky Lviv National Medical University

author

Nazar Manko

• Institute of Cell Biology, NAS Ukraine

author

Lidiia Panchak

• 1Danylo Halytsky Lviv National Medical University

author

Semen Khomyak

• Lviv Polytechnic National University

author

Rostyslav Stoika

• Ivan Franko National University of Lviv

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• Document Type: article