Znaczenie procesów angiogenezy w patofizjologii astmy oskrzelowej

• Authors: Maciej Chałubiński , Marek L. Kowalski

Title variants

EN

The role of angiogenesis in the pathophysiology of bronchial asthma

• Languages of publication: PL EN

Abstracts

PL

Przewlekłemu zapaleniu w przebiegu astmy oskrzelowej towarzyszy rozbudowa sieci naczyń krwionośnych w drogach oddechowych. Wzmożone procesy angiogenezy u chorych na astmę odzwierciedlają zwiększone zapotrzebowanie tkanek na tlen i substancje odżywcze i wynikają z nadmiernej aktywności licznych czynników proangiogennych uwalnianych zarówno przez tkanki budujące ścianę oskrzeli (nabłonek oddechowy, przerośnięte mięśnie gładkie, fibroblasty), jak również produkowane przez komórki immunologiczne i cytokiny typu Th2. W odpowiedzi na alergen dochodzi też do zwiększonej rekrutacji progenitorowych komórek śródbłonka naczyniowego do płuc. W efekcie rozbudowana sieć naczyń krwionośnych u chorych na astmę sprzyja podtrzymywaniu zapalenia i jest ważnym czynnikiem przebudowy dróg oddechowych prowadzącej do nieodwracalnych zmian strukturalnych. Oddziaływanie na angiogenezę może stać się w przyszłości kolejnym filarem leczenia astmy oskrzelowej.

EN

Chronic inflammation in asthma is accompanied by the increased vascular network in airways. Increased neovascularization occurs due to higher tissue demands for the oxygen and nutrients and results from the increased activity of proangiogenic factors released by tissues in airways (bronchial epithelium, smooth muscle cells, fibroblasts) as well as the immune cells and Th2-derived cytokines. Enhanced recruitment of progenitor endothelial cells occurs in response to allergen exposition. Intensified vascular network in asthma facilitates inflammation and supports bronchial remodeling leading to irreversible structural changes. In the future, modulation of angiogenesis may become another way of asthma treatment.

Keywords

EN

alergia; angiogeneza; astma; przebudowa; śródbłonek

Discipline

• MEDICINE: MEDICINE

• Publisher: Oficyna Wydawnicza Mediton
• Journal: Alergia Astma Immunologia - przegląd kliniczny
• Year: 2017
• Volume: 22
• Issue: 1
• Pages: 12-16

Contributors

author

Maciej Chałubiński

• Klinika Immunologii, Reumatologii i Alergii, Uniwersytet Medyczny w Łodzi

author

Marek L. Kowalski

• Klinika Immunologii, Reumatologii i Alergii, Uniwersytet Medyczny w Łodzi

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• Document Type: article