EVALUATION OF HYDROPHILIC GLOBULES WITH SODIUM ALGINATE CONTAINING A LACTIC ACID– CHITOSAN COMPLEX

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

An important issue in the treatment of vaginitis is the amount of time the drug remains on the vaginal mucosa. If the contact time is too short, the drug cannot work effectively to ensure the correct pH in the vaginal environment. This study evaluated formulations of globules containing sodium alginate, lactic acid and chitosan with different pH and rheological properties. The experimental studies revealed that it is possible to produce a preparation with optimal pharmaceutical and application properties. The use of an appropriate ratio of lactic acid to chitosan in the complex and the appropriate concentration of sodium alginate produces a preparation with excellent properties to coat the surface of the vaginal mucosa.

Keywords

EN

anti-inflammatory drugs; hydrophilic globules; lactic acid-chitosan complex; physiological environment of vagina; vaginal infections.; vaginal mucosa

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2021
• Volume: 26
• Pages: 170-177

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Department of Drugs Form Technology, Faculty of Pharmacy The “Silesian Piasts” memorial Wroclaw Medical University,

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• Document Type: article