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2015 | 20 | 64-72
Article title

THE STUDY OF PHYSICOCHEMICAL PROPERTIES OF SOLID DISPERSIONS OF IBUPROFEN IN THE PRESENCE OF CHITOSAN

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EN
Abstracts
EN
The aim of the present study was to increase the solubility of ibuprofen. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Solid dispersion obtained. Ibuprofen was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of ibuprofen and chitosan (1:9. 3:7 and 5:5). Formulations were tested dissolution rate of the ibuprofen. The highest dissolution of ibuprofen, amounting to 12.59%, was observed after 60 minutes from solid dispersion prepared by the evaporation method and 12.18% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 60-fold. XRPD analysis indicates the presence of the ibuprofen in amorphous form in the solid dispersion obtained by the modified solvent evaporation.
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Year
Volume
20
Pages
64-72
Physical description
Contributors
  • Faculty of Pharmacy, The „Silesian Piasts” memorial Medical University of Wroclaw ul Borowska 211a, 50-556 Wroclaw, Poland, bozena.grimling@umed.wroc.pl
author
  • Faculty of Pharmacy, The „Silesian Piasts” memorial Medical University of Wroclaw ul Borowska 211a, 50-556 Wroclaw, Poland
  • Faculty of Pharmacy, The „Silesian Piasts” memorial Medical University of Wroclaw ul Borowska 211a, 50-556 Wroclaw, Poland
author
  • Faculty of Pharmacy, The „Silesian Piasts” memorial Medical University of Wroclaw ul Borowska 211a, 50-556 Wroclaw, Poland
  • Faculty of Pharmacy, The „Silesian Piasts” memorial Medical University of Wroclaw ul Borowska 211a, 50-556 Wroclaw, Poland
References
  • 1. Park Y,J, Kwon R., Quan Q,Z, Oh D,H, Kin J,O, Hwong M.,R., Koo Y,B, Woo J,S., Yong C,S, & Choi H.,G; (2009) Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution. Arch Pharm Res 32, 767-772. DOI: 10.1007/s12272-009-1516-3
  • 2. Patel R, Patel N, Patel NM;. (2010) A novel approach for dissolution enhancement of Ibuprofen by preparing floating granules. Int. J Res Pharm Sci 1, 57-64.
  • 3. Gupta MM, Patel M, Patel NM, Madhulika K; (2011) Enhancement of dissolution rate of ibuprofen by preparing solid dispersion using different methods. Int J Pharm Pharm Sci 3, 204-206.
  • 4. Jain SK, Shukla M, Shrivastava V; (2012). Development and in vitro evaluation of ibuprofen mouth dissolving tablets using solid dispersion technique. Chemical & Pharmaceutical Bulletin 58, 1037-1042.
  • 5. Czechowska-Biskup R., Jarosińska D, Rokita B, Ulański P, Rosiak JM; (2012) Determination of degree of deacetylation of chitosan - comparision of methods. Progress on Chemistry and Application of Chitin and Its Derivatives 17, 5-20.
  • 6. Zhong L1, Zhu X, Luo X, Su W. (2013). Dissolution properties and physical characterization of telmisartan-chitosan solid dispersions prepared by mechanochemical activation, AAPS Pharm.Sci.Tech. 14, 541-550.
Document Type
article
Publication order reference
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YADDA identifier
bwmeta1.element.psjd-b6beea75-21a2-4876-8ce9-ae0b7dd2901e
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