Multiple debulking surgery and triple antifungal therapy in abdominal-cardiac-pulmonary invasive aspergillosis

• Authors: Przemysław Gałązka , Ewa Demidowicz , Natalia Bartoszewicz , Krzysztof Czyżewski , Zbigniew Serafin , Patrycja Zalas-Więcek , Jan Styczyński
• Languages of publication: EN

Abstracts

EN

Children with acute leukemia are at a high risk of invasive fungal disease, which might manifest itself as clinically-resistant entity. The objective of this paper is to present an unusual clinical case of 17-year-old patient treated for acute lymphoblastic leukemia, with early development of disseminated invasive aspergillosis, involving the abdominal, pulmonary and cardiac structures. The patient was subjected to a combined targeted double, and later triple, antifungal therapy together with several debulking surgical interventions. The clinical course indicated a highly clinically-resistant invasive fungal disease, and the treatment was unsuccessful in this case. Limited current experience in triple antifungal therapy, abdominal aspergillosis, Aspergillus endocarditis, and possible causes of failure of antifungal therapy are discussed in the paper.

Keywords

EN

abdominal aspergillosis; invasive disseminated aspergillosis; invasive fungal disease; tripleantifungal therapy

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Education
• Journal: OncoReview
• Year: 2018
• Volume: 8
• Issue: 2
• Pages: 33-37

Contributors

author

Przemysław Gałązka

• Clinical Ward of General and Oncological Surgery for Children and Adolescents, Collegium Medicum, Nicolaus Copernicus University, A. Jurasz University Hospital No. 1, Bydgoszcz

author

Ewa Demidowicz

• Department of Pediatrics, Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, A. Jurasz University Hospital No. 1, Bydgoszcz

author

Natalia Bartoszewicz

• Department of Pediatrics, Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, A. Jurasz University Hospital No. 1, Bydgoszcz

author

Krzysztof Czyżewski

• Department of Pediatrics, Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, A. Jurasz University Hospital No. 1, Bydgoszcz

author

Zbigniew Serafin

• Department of Radiology and Imaging Diagnostics, Collegium Medicum, Nicolaus Copernicus University, A. Jurasz University Hospital No. 1, Bydgoszcz

author

Patrycja Zalas-Więcek

• Department of Microbiology, Collegium Medicum, Nicolaus Copernicus University, A. Jurasz University Hospital No. 1, Bydgoszcz

author

Jan Styczyński

• Department of Pediatrics, Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, A. Jurasz University Hospital No. 1, Bydgoszcz

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• Document Type: article