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2019 | 119 | 41-51
Article title

AGEs interactions with RAGE and their contribution to diabetic retinopathy

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Abstracts
EN
Diabetic retinopathy as a complication of diabetes is one of the most common causes of vision loss. It is a dangerous disease, which affects more and more people. It is important to know its different causes, background and to generate new, effective therapeutic threatments. One of the possible causes of diabetic retinopathy is the accumulation of advanced glycation products and over-expression of AGEs receptors (RAGE) leading to tissue damage, oxidative stress formation, and the promotion of other changes and disorders. There are many genetic variants that encode the AGEs receptor (RAGE). Some polymorphisms (Gly82Ser, 1704G/T, 2184A/G, -429T/C, -374T/A) may be associated with diabetic retinopathy. This paper aims to systematize knowledge in this field and to show the relationship between these compounds and diabetic retinopathy.
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119
Pages
41-51
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author
  • University of Zielona Góra, Faculty of Biological Sciences, Department of Biotechnology, Prof. Szafran Str. 1, PL 65-516 Zielona Góra, Poland
  • University of Zielona Góra, Faculty of Biological Sciences, Department of Biotechnology, Prof. Szafran Str. 1, PL 65-516 Zielona Góra, Poland
  • University of Zielona Góra, Faculty of Biological Sciences, Department of Biotechnology, Prof. Szafran Str. 1, PL 65-516 Zielona Góra, Poland
  • Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Faculty of Medicine, University Hospital No. 1, Department of Eye Diseases, M. Skłodowska-Curie Str. 9, PL 85-092 Bydgoszcz, Poland
  • University of Technology and Life Sciences, Faculty of Animal Breeding and Biology, Department of Genetics and Animal Breeding, Mazowiecka Str. 28, PL 85-084 Bydgoszcz, Poland
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Document Type
article
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Identifiers
YADDA identifier
bwmeta1.element.psjd-b2475e27-dca3-4220-9133-c471d9675c99
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