Effects of Exercise on Appetite-Regulating Hormones, Perceived Hunger, and Energy Intake: A Narrative Overview
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Controlling appetite, perceived hunger, and energy intake are important factors in weight management. This narrative review examines the effect of different forms, intensities and duration of exercise on the appetite-regulating hormones leptin, acylated ghrelin, glucagon like peptide-1 (GLP-1) and peptide tyrosine tyrosine3-36 (PYY3-36), perceptions of hunger, and energy intake in overweight/obese, and normal weight populations. The studies reviewed compared exercise intensities- low, moderate, and high intensity, and modes of exercise- aerobic and resistance training. The studies selected in this narrative review included participants that ranged in age from 13-57 years old, male and female, previously sedentary and physically active, and normal weight and overweight/obese individuals- defined by body mass index standards (BMI). The primary benefits of exercise on appetite regulation are seen with moderate to high-intensity aerobic exercise; with the most notable relative energy deficit resulting from an exercise bout (at any intensity) that expends the most energy. Further research is warranted to determine if there exists a tendency to overcompensate for energy expended during exercise in certain populations.
- California University of Pennsylvania, Department of Exercise Science & Health Promotion, California, USA
- London School of Hygiene & Tropical Medicine, Department of Global Health & Development, London, United Kingdom
- A.T. Still University of Health Sciences, College of Graduate Health Studies, Kirksville, USA
- University of Szczecin, Faculty of Physical Education and Health Promotion, Szczecin, Poland
- Broom, D.R., Batterham, R.I., King, J.A., Stensel, D.J. (2009). Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptite YY in healthy males. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 296 (1), 29–35. DOI: 10.1152/ajpregu.90706.2008.
- Campolier, M., Thondre, S.P., Clegg, M., Shafat, A., Mcintosh, A., Lightowler, H. (2016). Changes in PYY and gastric emptying across the phases of the menstrual cycle and the influence of the ovarian hormones. Appetite, 107, 106–115. DOI: 10.1016/j. appet.2016.07.027.
- Caudwell, P., Gibbons, C., Finlayson, G., Naslund, E., Blundell, J. (2013). Physical activity, energy intake, and obesity: the links between exercise and appetite. Current Obesity Reports, 2 (2), 185–190. DOI: 10.1007/s13679-013-0051-1.
- Centers for Disease Control and Prevention (2016). Current physical activity guidelines. Retrieved from: https://www.cdc.gov/cancer/ dcpc/prevention/policies_practices/physical_ activity/guidelines.htm.
- Deighton, K., Barry, R., Connon, C.E., Stensel, D.J. (2013). Appetite, gut hormone and energy intake responses to low volume sprint and traditional endurance exercise. European Journal of Applied Physiology, 113, 1147–1156. DOI: 10.1007/s00421-012-2535-1.
- Deighton, K., Karra, E., Batterham, R.L., Stensel, D.J. (2013). Appetite, energy intake, and PYY3-36 responses to energy-matched continuous exercise and submaximal high-intensity exercise. Applied Physiology Nutrition and Metabolism, 38, 947–952. DOI: 10.1139/apnm-2012-0484.
- Douglas, J.A., King, J.A., McFarlane, E., Baker, L., Bradley, C., Crouch, N., …, Stensel, D.J. (2015). Appetite, appetite hormone and energy intake responses to two consecutive days of aerobic exercise in healthy young men. Appetite, 92 (1), 57–65. DOI: 10.1016/j.appet.2015.05.006.
- Douglas, J.A., King, J.A., Clayton, D.J., Jackson, A.P., Sargeant, A., Thackray, E., …, Stensel, D.J. (2017). Acute effects of exercise on appetite, ad libitum energy intake and appetite-regulatory hormones in lean and overweight/obese men and women. International Journal of Obesity, 41 (12), 1737–1744. DOI: 10.1038/ijo.2017.181.
- Erdmann, J., Tahbaz, R., Lippl, F., Wagenpfeil, S., Schusdziarra, V. (2007). Plasma ghrelin levels during exercise – effects of intensity and duration. Regulatory Peptides, 143 (1–3), 127–135. DOI: 10.1016/j.regpep.2007.05.002.
- Flint, A., Raben, A., Blundell, J.E., Astrup, A. (2000). Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. International Journal of Obesity Related Metabolic Disorders, 24, 38–48. DOI: 10.1038/sj.ijo.0801083.
- Fryar, C.D., Carroll, M.D., Ogden, C.L. (2016). Prevalence of overweight, obesity, and extreme obesity among adults aged 20 and over: United States 1960–1962 through 2013–2014. National Center for Health Statistics Health E-Stats. Retrieved from: https://www. cdc.gov/nchs/data/hestat/obesity_adult_13_14/obesity_adult_13_14.pdf.
- Guelfi, K.J., Donges, E.D., Duffield, R. (2013). Beneficial effect of 12 weeks of aerobic compared with resistance exercise training on perceived appetite in previously sedentary overweight and obese men. Metabolism, 62 (2), 235–243. DOI: 10.10.16/j. metabol.2012.08.002.
- Hagobian, T.A., Sharoff, C.G., Stephens, B.R., Wade, G.N., Silva, G.E., Chipkin, S.R., Braun, B. (2009). Effects of exercise on energyregulating hormones and appetite in men and women. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 296 (2), 233–242. DOI: 10.1152/ajpregu.90671.2008.
- Hagobian, T.A., Yamashiro, M., Hinkel-Lipsker, J., Streder, K., Evero, N., Hackney, T. (2013). Effects of acute exercise on appetite hormones and ad libitum energy intake in men and women. Applied Physiology Nutrition and Metabolism, 38, 66–72. DOI: 10.1139/apnm-2012-0104.
- Howe, S.M., Hand, T.M., Larson-Meyer, D.E., Austin, K.J., Alexander, B.M., Manore, M.M. (2016). No effect of exercise intensity on appetite in highly-trained endurance women. Nutrients, 8, 223. DOI: 10.3390/nu8040223.
- King, J.A., Wasse, L.K., Broom, D.R., Stensel, D.J. (2010). Influence of brisk walking on appetite, energy intake, and plasma acylated ghrelin. Medicine & Science in Sports & Exercise, 42 (3), 485–492. DOI: 10.1249/MSS.0b013e3181ba10c4.
- Klok, M.D., Jakobsdottir, S., Drent, M.L. (2007). The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obesity Reviews, 8 (1), 21–34. DOI: 10.1111/j.1467-789X.2006.00270.x.
- Kojima, C., Ishibashi, A., Ebi, K., Goto, K. (2016). The effect of a 20km run on appetite regulation in long distance runners. Nutrients, 8 (672), 1–13. DOI: 10.3390/nu8110672.
- Laan, D.J., Leidy, H.J., Lim, E., Campbell, W.W. (2010). Effects and reproducibility of aerobic and resistance exercise on appetite and energy intake in young, physically active adults. Applied Physiology, Nutrition, and Metabolism, 35, 842–847. DOI: 10.1139/ H10-072.
- Martins, C., Stensvold, D., Finlayson, G., Holst, J., Wisloff, U., Kulseng, B., ..., King, N.A. (2015). Effect of moderate- and high-intensity acute exercise on appetite in obese individuals. Medicine and Science in Sports and Exercise, 47 (1), 40–48. DOI: 10.1249/ MSS.000000000000372.
- Prado, W.L., Lofrano-Prado, M.C., Cardel, M., Balagopal, P., Oyama, L.M., Praxedes-Gomes, P., ..., Hill, J.O. (2015). Effect of a 12-week low vs. high intensity aerobic exercise training on appetite-regulating hormones in obese adolescents: a randomized exercise intervention study. Pediatric Exercise Science, 27, 510–517. DOI: 10.1123/pes.2015-0018.
- Vantansever-Ozen, S., Tiryaki-Sonmez, G., Bugdayci, G., Ozen, G. (2011). The effects of exercise on food intake and hunger: relationship with acylated ghrelin and leptin. Journal of Sports Science and Medicine, 10, 283–291. Retrieved from: http://www. jssm.org/gecjssm-10-283.xml.xml.
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