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2020 | 31 | 110-119

Article title

Evaluation Cephalosporins Resistance in Pathogenic Bacteria Isolated Clinically

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EN

Abstracts

EN
Third-generation cephalosporins are a class of b-lactam antibiotics that are often used for the treatment of human infections caused by Gram-negative and gram-positive bacteria. This study aimed to detect the pattern of bacterial antibiotic sensitivity to the third generation of cephalosporins that assist doctors with appropriate empirical therapy. For study purposes, various bacteria were isolated clinically from urine, high vaginal swab (cervical swab), ear and wound samples during the period from November 2019 to March 2020 at Al-Shomali general hospital, Babil, Iraq and a private laboratory in Babil city. A total of 154 patients were involved in this study, samples were processed at the hospital laboratory during this period, diagnosis and antibiotic sensitivity test having been done by routine bacteriological diagnosis, as well as by VITEK 2 system. Three common third-generation cephalosporins; cefotaxime, Cefotazidime, and ceftriaxone were evaluated. Out of these 154 samples, 46 (30%) have bacterial growth. Specimens with bacterial growth were taken from urine, cervical swab, ear discharge and wound infection, the counts being 24, 8, 8, and 6 respectively. All 46 isolated bacteria were 100% resistant to cefotaxime and Cefotazidime, while 36 (78%) were resistant to ceftriaxone. The prevalence of bacterial isolation in different specimens showed a high predominance of Enterococcus spp 16 (35%) from the total samples. The current study revealed that the increasing burden of bacterial resistance to third-generation cephalosporins, especially to cefotaxime and Cefotazidime, may due to misuse and inappropriate high administration of these drugs. This should be countered by early detection of development third-generation resistance in patients by restricted clinical monitoring and through judicious use of antibiotics. Of note, the highest rate of resistance was observed in age groups less than 15 years old.

Year

Volume

31

Pages

110-119

Physical description

Contributors

  • Department of Microbiology, Al-Shomali General Hospital, Babil, Iraq
  • Department of Microbiology, Al-Shomali General Hospital, Babil, Iraq
  • Department of Microbiology, Al-Shomali General Hospital, Babil, Iraq
  • Department of Microbiology, Al-Shomali General Hospital, Babil, Iraq

References

  • [1] Arumugham VB, Cascella M. Third Generation Cephalosporins. InStatPearls 26 (2019) 33-36
  • [2] Pfeifer Y, Cullik A, Witte W. Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogens. International Journal of Medical Microbiology 300 (2010) 371-379
  • [3] AL Khikani FH, Al Janabi AA. Topical amphotericin B formulas: Promising new application. IntJ Med Sci Curr Res 2 (2019) 187 96
  • [4] AL Khikani FH. Pulmonary mycoses treated by topical amphotericin B. Biomed Biotechnol Res J 4 (2020) 65-69
  • [5] AL-Khikani FH, Auda Ga, Ayit AS. Correlation study between urinary tract bacterial infection and some acute inflammatory responses. Biomed Biotechnol Res J 3 (2019) 236-239
  • [6] Farhadi Z, Bahador N. Pathotypic and phylogenetic studies of urine Escherichia coli isolates from girls<5 years of age in Marvdasht hospital. Biomed Biotechnol Res J 2 (2018) 281-284
  • [7] Alkhudhairy MK, Saki M, Seyed-Mohammadi S, Jomehzadeh N, Khoshnood S, Moradzadeh M, et al. Integron frequency of Escherichia coli strains from patients with urinary tract infection in Southwest of Iran. J Acute Dis 8 (2019) 113-117
  • [8] Mehrishi P, Faujdar SS, Kumar S, Solanki S, Sharma A. Antibiotic susceptibility profile of uropathogens in rural population of Himachal Pradesh, India: Where we are heading? Biomed Biotechnol Res J 3 (2019) 171-175
  • [9] Berrazeg M, Jeannot K, Enguéné VY, Broutin I, Loeffert S, Fournier D, Plésiat P. Mutations in β-lactamase AmpC increase resistance of Pseudomonas aeruginosa isolates to antipseudomonal cephalosporins. Antimicrobial agents and chemotherapy 59 (2015) 6248-55
  • [10] Gajul SV, Mohite ST, Datkhile KD, Kakade SV, Mangalagi SS, Wavare SM. Prevalence of Extended Spectrum Beta Lactamase Genotypes in Klebsiella pneumoniae from Respiratory Tract Infections at Tertiary Care Hospital. Journal of Krishna Institute of Medical Sciences 8 (2019) 4-8
  • [11] AL Khikani FH, Abadi RM, Ayit AS. Emerging carbapenemase Klebsiella oxytoca with multidrug resistance implicated in urinary tract infection. Biomed Biotechnol Res J 4 (2020) 66-68
  • [12] Paterson DL, Siu KL, Chang FY. Klebsiella species (K. pneumoniae, K. oxytoca, K. ozaenae and K. rhinoscleromatis). Antimicrobe 9 (2014) 74-76
  • [13] AL Khikani FH, Almosawey HS. Be conscious to be healthy: An initiative to prevent recurrent urinary tract infection in Iraqi women. Hamdan Med J 12 (2020) 44-46
  • [14] AL Khikani FH, The forgotten role of methenamine to prevent recurrent urinary tract infection: urgency for reuse 100 years after discovery. Pharmaceutical and Biomedical Research 6 (2020) 13-16

Document Type

article

Publication order reference

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YADDA identifier

bwmeta1.element.psjd-b11aa4fa-29cc-46a7-964d-c56874f76778
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