THE EFFECT OF POLOXAMER 407 ON THE PROPERTIES OF HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

Anatomical and physiological conditions in the vagina do not facilitate easy application of the drug neither its maintenance on the site of application. Insufficient duration of the drug’s contact with vaginal mucosa does not provide adequate pH conditioning the physiological biocenosis of the organ. Gels containing lactic acid complexed with chitosan at a stechiometric ration 1:1 and 2:1 and 5 - 25% content of PEG-200 are able to move from 25 to 30 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 20 to 24 cm. The addition of 20 – 25% poloxamer 407 increases the pH to 4.55 to 5.30 for 1:1 gels and 4.00 to 4.85 for 2:1 gels. The investigations showed that the addition of a thermosensitive polymer increases the adhesive properties of the investigated gels. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing poloxamer 407 in comparison to the reference gels.

Keywords

EN

anti-inflammatory drugs.; chitosan; complex; lactic acid; poloxamer 407; vaginal infections

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2010
• Volume: 15
• Pages: 143 - 148

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw

References

• Schwebke J. R.; (2009) New Concepts in the Etiology of Bacterial Vaginosis. Curr. Infect. Dis. Rep. 11, pp. 143-147.
• Denney J. M., Culhane J. F.; (2009) Bacterial vaginosis: A problematic infection from both a perinatal and neonatal perspective. Sem. Fet. & Neonat. Med. 14, pp. 200-203.
• Kubis A. A., Małolepsza-Jarmołowska K.; (1996) Studies on gynecological hydrophiling preparations comprising lactic acid. Part 1: Effects of lactic acid and hydrophiling agents on physical and chemical properties of methylcellulose gels. Pharmazie 51, pp. 989-990.
• Małolepsza-Jarmołowska K., Kubis A. A.; (1999) Studies on gynecological hydrophilic lactic acid preparations. Part 2: Effects of Eudragit® E-100 on properties of methylcellulose gels. Pharmazie 54, pp. 441-443.
• Małolepsza-Jarmołowska K., Kubis A. A.; (2000) Studies on gynaecological hydrophilic lactic acid preparations. Part 3: Effects of chitosan on the properties of methylcellulose gels. Pharmazie 55, pp. 610-611.
• Małolepsza-Jarmołowska K., Kubis A. A.; (2001) Studies on gynaecological hydrophilic lactic acid preparations. Part 4: Effects of polyvinyl pyrrolidone K-90 on properties of methylcellulose gels. Pharmazie 56, pp. 160-162.
• Małolepsza-Jarmołowska K., Kubis A. A., Hirnle L.; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 5: The use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie 58, pp. 260-262.
• Małolepsza-Jarmołowska K., Kubis A. A., Hirnle L.; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 6: Use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie 58, pp. 334-336.
• Małolepsza-Jarmołowska K.; (2006) Studies on gynaecological hydrophilic lactic acid preparations. Part 7: Use of chitosan as lactic acid carrier in intravaginal tablets (globuli vaginales). Pharmazie 61, pp. 780-782.
• Małolepsza-Jarmołowska K.; (2007) Studies on gynaecological hydrophilic lactic acid preparations. Part 8: Use of chitosan as lactic acid carrier in intravaginal tablets. Acta Pol. Pharm. 64, pp. 69-72

• Document Type: article