The genetic diversity of HLA DRB1* alleles among Indian and African populations
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The HLA system is highly polymorphic and commonly used as a marker to understand core population genetical aspects such as stratification, human migration, predisposition to diseases and tissue transplantation compatibility. Although HLA alleles are generally treated as equidistant molecular units in population genetic studies, the diversity of DNA allelic frequencies among populations is also considered to be crucial to interpret the observed HLA polymorphisms. This study compares the variation of HLA DRB1 alleles across various subgroups of both Indian and African Populations, using their respective allelic frequencies. The HLA DRB1 allelic frequencies for 3,153 individuals of 32 subgroups of both Indian and African populations, were collected from the Allele Frequency Net Database (AFND). Correlation matrix and Grid diagram were compiled using the R statistical package. Allele frequencies were analyzed for the respective population subgroups using XLSTAT. The North East Indian populations were completely devoid of HLA DRB1* 16, which is fairly present in south Indian populations. The South Indian populations harbor both HLA DRB1* 10 and HLA DRB1* 15 at relatively higher levels but are very scarce of HLA DRB1* 07, HLA DRB1* 09, HLA DRB1* 12 and HLA DRB1* 13. The alleles HLA DRB1* 03, HLA DRB1* 04 and HLA DRB1* 07 could represent an epicenter for the admixture of African, North-East Indian and South Indian populations.
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