THE INFLUENCE OF SELECTED POLYMERS ON THE RHEOLOGICAL PROPERTIES OF HYDROGELS WITH CHITOSAN APPLIED ON THE SKIN

• Authors: Maria Szcześniak , Bożena Grimling , Jan Meler , Bożena Karolewicz
• Languages of publication: EN

Abstracts

EN

The aim of the study was to evaluate the effect of methylcellulose and carboxymethylcellulose on the rheological properties of hydrogels applied to skin on chitosan in the presence of the additives propylene glycol and glycerol. Rheological studies showed that the tested gels are non-newtonian systems, and have thixotropic properties. Substrates made of methylcellulose and chitosan are characterised by higher shear values than those obtained with carboxymethylcellulose. The addition of polymers had a positive influence on the dispersion of hydrogels, and the addition of excipients increased firmness, consistency and cohesiveness of the gels. Larger increases were observed with the addition of 10% of glycol propylene and glycerol contents for methylcellulose and of 20% of carboxymethylcellulose.

Keywords

EN

chitosan; hydrogels; pharmaceutical availability; rheological parameters

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2017
• Volume: 22
• Pages: 201 - 206

Contributors

author

Maria Szcześniak

• Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland

author

Bożena Grimling

• Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland

author

Jan Meler

• Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland

author

Bożena Karolewicz

• Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland

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• Document Type: article