PL EN


Preferences help
enabled [disable] Abstract
Number of results
2017 | 22 | 201 - 206
Article title

THE INFLUENCE OF SELECTED POLYMERS ON THE RHEOLOGICAL PROPERTIES OF HYDROGELS WITH CHITOSAN APPLIED ON THE SKIN

Content
Title variants
Languages of publication
EN
Abstracts
EN
The aim of the study was to evaluate the effect of methylcellulose and carboxymethylcellulose on the rheological properties of hydrogels applied to skin on chitosan in the presence of the additives propylene glycol and glycerol. Rheological studies showed that the tested gels are non-newtonian systems, and have thixotropic properties. Substrates made of methylcellulose and chitosan are characterised by higher shear values than those obtained with carboxymethylcellulose. The addition of polymers had a positive influence on the dispersion of hydrogels, and the addition of excipients increased firmness, consistency and cohesiveness of the gels. Larger increases were observed with the addition of 10% of glycol propylene and glycerol contents for methylcellulose and of 20% of carboxymethylcellulose.
Publisher

Year
Volume
22
Pages
201 - 206
Physical description
Contributors
  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland, maria.szczesniak@umed.wroc.pl
  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland
author
  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland
  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland
References
  • Szcześniak M., Pluta J; (2012) Hydrożele. Farm. Pol. 7, 458–461
  • Ullah F., Othman M. B. H., Javed F., Ahmad Z., Akil H. M; (2015) Classification, processing and application of hydrogels: A review. Mater. Sci. Eng. C, 57, 414–433 DOI: 10.1016/j.msec.2015.07.053 [3] Górska A., Jachowicz R., Dorożyński P; (2015) Hydrogels as a modern dressings form for pressure ulcers Farm. Pol. 3, 185–189.
  • Kamel S., Ali N., Jahangir K., Shah S. M., El-Gendy A. A; (2008) Pharmaceutical significance of cellulose: A review. Express Polym. Lett. 2(11), 758–778. DOI: 10.3144/expresspolymlett.2008.90.
  • Juncu G., Stoica-Guzun A., Stroescu M., Isopencu G., Jinga S. I; (2016) Drug release kinetics from carboxymethylcellulose-bacterial cellulose composite films. Int. J. Pharm. 510, 485–492
  • Zawadzka E; (2007) Formulation of anti-inflammatory eye drops with methylcellulose solubilized with micellar solutions of polyether-n-ols. Farm. Pol. 10, 449–454. [7] Wang Y., Lapitsky Y., Kang C. E., Shoichet M. S; (2009) Accelerated release of a sparingly soluble drug from an injectable hyaluronan–methylcellulose hydrogel. J. Control Release 140(3), 218–223. DOI: 10/1016/j.jconrel.2009.05.025
  • Park C. H., Jeong L., Cho D., Kwon O. H., Park W. H; (2013) Effect of methylcellulose on the formation and drug release behavior of silk fibroin hydrogel. Carb. Polym. 98(1), 1179–1185. DOI: 10.1016/j.carbpol.2013.07.028.
  • Li H. Y., Song X., Seville P. C; (2010) The use of sodium carboxymethylcellulose in the preparation of spray-dried proteins for pulmonary drug delivery. Eur. J. Pharm. Sci. 40(1), 56–61. DOI: 10.1016/j.ejps.2010.02.007.
  • Szcześniak M., Gasztych M., Pluta J; (2013) Effect of the medium composition on the properties of gels based on sodium carboxymethylcellulose. Polim. Med. 43, 235–239.
  • Sobczak M., Olędzka E., Kołodziejski W.L., Kuźmicz R; (2007) Polymers for pharmaceutical applications. Polim. 52(6), 411–420.
  • Michalak D., Orkowska J., Szcześniak M; (2011) Chitin derivatives – application in tissue engineering and design for active dressings. Farm. Pol. 67(12), 867–872.
  • Szcześniak M., Pluta J; (2013) The effect of selected excipients on the properties hydro gels on the basis Carbopol 934 P. Polim. Med. 43, 29–34.
  • Szcześniak M., Pluta J; (2011) Influence of polymers on hydrogels with hydrocortisone properties. Polim. Med. 41(2), 43–48.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-ab8342e0-4e22-4237-a25e-433e0577ad3d
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.