Computational study of ACE and AGT gene of RAAS pathway

• Authors: Nisha Nisha , Satbir Kaur , Sumanpreet Kaur , Sandeep Kumar , Kiranjeet Kaur Galhna , Kamaljeet Kaur
• Languages of publication: EN

Abstracts

EN

Renin angiotensin aldosterone system (RAAS) is a hormone regulatory hormone system that regulate blood pressure. The two major genes ACE and AGT are the players of RAAS pathway. These genes codes for angiotensin convertase enzyme and angiotensinogen protein respectively. The angiotensin convertase enzyme convert inactive angiotensinogen into active angiotensin which further helps in the regulation of blood pressure. Due to imbalance in this pathway may cause hypertension. So in the present study we decided to perform the computational study of ACE and AGT gene. We evaluated the deleterious/damaging effect of SNPs of ACE and AGT gene by SIFT and I-Mutant2.0. The total number of SNPs predicted to be deleterious by both tools were 5 (1.83%) and 22 (6.07%) for AGT and ACE genes respectively. We also studied subcellular location of ACE and AGT genes and drugs targeting these genes from database GeneCards. Further the result output of both the softwares were also compared.

Keywords

EN

Angiotensin converting enzyme; Angiotensinogen; Hypertension; Renin angiotensin aldosterone system; Single nucleotide polymorphism

Discipline

• GENETICS: GENETICS

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2018
• Volume: 19
• Pages: 65-77

Contributors

author

Nisha Nisha

• Department of Human Genetics, Punjabi University, Patiala 147002, India

author

Satbir Kaur

• Department of Human Genetics, Punjabi University, Patiala 147002, India

author

Sumanpreet Kaur

• Department of Human Genetics, Punjabi University, Patiala 147002, India

author

Sandeep Kumar

• Department of Human Genetics, Punjabi University, Patiala 147002, India

author

Kiranjeet Kaur Galhna

• Department of Human Genetics, Punjabi University, Patiala 147002, India

author

Kamaljeet Kaur

• Department of Human Genetics, Punjabi University, Patiala 147002, India

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• Document Type: article