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2019 | 126 | 148-162
Article title

4-(3-(2-amino-3,5-dibromophenyl)-1-(4-substitutedbenzoyl)-4,5-dihydro-1H-pyrazol-5-yl)benzonitrile as a novel anti-Inflammatory scaffold: synthesis, biological evaluation and docking studies

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Abstracts
EN
A new series, 4-(3-(2-amino-3,5-dibromophenyl)-1-(4-substitutedbenzoyl)-4,5-dihydro-1H-pyrazol-5-yl)benzonitrile (4a-h), were synthesized and evaluated for in vitro anti-inflammatory activities. The spectral (IR, NMR) and elemental analyses data of the product indicated the formation of new pyrazoles 4a-h. Compound 4e exhibited potent anti-inflammatory property about 85.45 % inhibitions. This value was compared with standard diclofenac sodium. Additionally, molecular docking increased our understanding of their receptor-ligand binding. These results demonstrated that pyrazole derivatives are potential inhibitors. Overall, the results suggest that the pyrazoles 4a-h is important lead compounds for the continuing battle against inflammation.
Year
Volume
126
Pages
148-162
Physical description
Contributors
author
  • Research and Development Centre, Bharathiar University, Coimbatore, 641046, India
author
  • Department of Chemistry, Govt Arts College, C. Mutlur, Chidambaram 608102, India
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Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-a8236f00-50bf-4e4e-acbb-80a0d0e0deeb
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