Solid acidic Bentonite/FeCl3 catalysed solvent-free cyclization of some aryl enones: Synthesis and assessment of antimicrobial potentials of some aryl pyrazolines

• Authors: G. Thirunarayanan , N. Dineshkumar , M. Rajarajan
• Languages of publication: EN

Abstracts

EN

Some aryl pyrazolines including 3-(substituted phenyl)-5-(naphthalen-1-yl)-1-phenyl-4,5-dihydro-1H-pyrazoles were prepared by microwave irradiation promoted cyclization of aryl enones and phenylhydrazine in the presence of solid acidic bentonite/FeCl3 catalyst under solvent-free conditions. In this cyclization the obtained yields are more than 75%. The structural analysis of these pyrazoline derivatives were confirmed through analytical and spectral techniques. The effect of catalyst and solvent on this cyclization also investigated through the obtained yields. The antimicrobial activities of these pyrazoline derivatives were assessed through measurement of mm of zone of inhibition against their micro stains using well known Bauer-Kirby disc diffusion method.

Keywords

EN

1; 3; 5-Substituted pyrazolines; Antimicrobial activities; Bentonite/FeCl3; IR and NMR Spectra; Solvent-free synthesis

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World Scientific News
• Year: 2019
• Volume: 117
• Pages: 14-28

Contributors

author

G. Thirunarayanan

• Department of Chemistry, Annamalai University, Annamalainagar - 608002, India

author

N. Dineshkumar

• Department of Chemistry, Annamalai University, Annamalainagar - 608002, India

author

M. Rajarajan

• Department of Chemistry, Thiruvalluvar Arts and Science College, Kurinjippadi - 607302, India

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• Document Type: article