Preferences help
enabled [disable] Abstract
Number of results
2019 | 117 | 14-28
Article title

Solid acidic Bentonite/FeCl3 catalysed solvent-free cyclization of some aryl enones: Synthesis and assessment of antimicrobial potentials of some aryl pyrazolines

Title variants
Languages of publication
Some aryl pyrazolines including 3-(substituted phenyl)-5-(naphthalen-1-yl)-1-phenyl-4,5-dihydro-1H-pyrazoles were prepared by microwave irradiation promoted cyclization of aryl enones and phenylhydrazine in the presence of solid acidic bentonite/FeCl3 catalyst under solvent-free conditions. In this cyclization the obtained yields are more than 75%. The structural analysis of these pyrazoline derivatives were confirmed through analytical and spectral techniques. The effect of catalyst and solvent on this cyclization also investigated through the obtained yields. The antimicrobial activities of these pyrazoline derivatives were assessed through measurement of mm of zone of inhibition against their micro stains using well known Bauer-Kirby disc diffusion method.
Physical description
  • Department of Chemistry, Annamalai University, Annamalainagar - 608002, India
  • Department of Chemistry, Annamalai University, Annamalainagar - 608002, India
  • Department of Chemistry, Thiruvalluvar Arts and Science College, Kurinjippadi - 607302, India
  • [1] V.H. Babu, C.H. Sridevi, A. Joseph, K.K. Srinivasan, Indian J. Pharm. Sci. 69, 2007, 470.
  • [2] G. Thirunarayanan and K. G. Sekar, J. Taibah Univ. Sci. 8, 2014, 124.
  • [3] K. Hazra, L. V. G. Nargund, P. Rashmi, J. N. NarendraSharath Chandra and B. Nandha, Der Chemica Sinica, 2(2), 2011, 149.
  • [4] M. F. EI Shehry, R. H. Swellem, Sh. M. Abu- Bakr, E. M. Ei-Telbani, Eur. J. Med. Chem. 45, 2010, 4783.
  • [5] E. Palaska, M. Aytemir, I. TayfunUzbay, D. Erol, Eur. J. Med. Chem. 36, 2001, 539.
  • [6] H. J. Park, K. Lee, S. Park, B. Ahn, J. C. Lee, H. Y. Cho, K. E. Lee, Bio Org. Med. Chem. Lett. 15, 2005, 3307.
  • [7] V.K. Ahluwalia, L. Nayal, N. Kalia, S. Bala and A. K. Tahim, Indian J. Chem. 26B, 1987, 384.
  • [8] A. Anees, Md. Siddiqui, M.d. Azizur Rahman, Md. Shaharyar, R, Mishra, Chem. Sci. J. 8, 2010, 1.
  • [9] S. Mukherjee, V. Kumar, A. K. Prasad, H. G. Raj, M. E. Brakhe, C. E. Olsen, S. C. Jain and V. S. Parmar, Med. Chem. 9, 2001, 337.
  • [10] C. K. Chu and J. J. Cutler, Heterocycl. Chem. 23, 1986, 289.
  • [11] C. Sridevi, K. Balaji, A. Naidu, S. Kavimani, D. Venkappayya, R. Suthakaran, R. Parimala. Int. J. Pharm. Tech. Res. 1, 2009, 816.
  • [12] K. Naik, Y. N. Spoorthy, L. R. K. R. Ravindranath and A. R. G. Prasad, J. Appl. Pharm. 4(1), 2013, 720.
  • [13] A. A. Siddiqui, M. A. Rahman, M. Shaharyar and R. Mishra, Chem. Sci. J. 1, 2010, 1.
  • [14] A. K. Bhatt, R. P. Bhamaria, M. R. Patel, R. A. Bellare and C. A. Deliwala, Indian J. Chem. 10, 1972, 694.
  • [15] D. M. Bailey, P. E. Hansen, A. G. Hlavac, E. R. Baizman, J. Pearl, A. F. Defelice and M. E. Feigenson, J. Med. Chem. 28, 1985, 256
  • [16] Z. Asim Kaplancikli, G. Turan-Zitouni, A. Ozdemir, O. Devrim Can, P. Chevallet, Eur. J. Med. Chem. 44(6), 2009, 2606.
  • [17] Z. Brozozowski and F. Saczewski; Eur. J. Med. Chem. 2002, 37, 709.
  • [18] T. S. Jeong, K.S. Kim, S. J. An, K. H. Cho, S. Lee, W.S. Lee. Bioorg Med Chem Lett. 14, 2004, 2715.
  • [19] B. A. Bhat, K. L. Dhar, S. C. Puri, M. Shanmugavel and G. N. Qazi, Bioorg. Med. Chem. Lett. 15(22), 2005, 5030.
  • [20] P.T. Chovatia, J. D. Akabari, P. K. Kachhadia, P. D. Zalavadia and H. S. Joshi, J. Serb. Chem. Soc. 71, 2007, 713.
  • [21] G. Vanangamudi, M. Subramanian, P. Jayanthi, R. Arulkumaran, D. Kamalakkannan, G. Thirunarayanan, Arab. J. Chem. 9(1), 2016, S717.
  • [22] G. Thirunarayanan, K. G. Sekar, Int. Lett. Chem. Phy. Astro. 25, 2014, 39.
  • [23] K. G. Sekar, G. Thirunarayanan, Int. Lett. Chem. Phy. Astro. 13, 2013, 249,
  • [24] G. Thirunarayanan, K. G. Sekar, Int. Lett. Chem. Phy. Astro. 36, 2014,193.
  • [25] G. Thirunarayanan, G. Vanangamudi, V. Sathiyendiran, K. Ravi, Indian J. Chem. 59B, 2011, 593.
  • [26] R. Senbagam, R. Vijayakumar, M. Rajarajan, S. Balaji, V. Manikandan, G. Vanangamudi and G. Thirunarayanan, Kar. Int. Jour. Mod. Sci. 2, 2016, 56.
  • [27] M. Rajarajan, R. Senbagam, R. Vijayakumar, S. Balaji, V. Manikandan, G. Vanangamudi, G. Thirunarayanan, Indian J. Chem. 55B, 2016, 197.
  • [28] S. P. Sakthinathan, G. Vanangamudi, G. Thirunarayanan, Spectrochim. Acta 95A, 2012, 693.
  • [29] G. Thirunarayanan and K.G. Sekar, Arab. J. Chem. 20, 2016, 661.
  • [30] G. Thirunarayanan and N. Dinesh Kumar, World Scientific News 74, 2017, 251.
  • [31] A. W. Bauer, W. M. M. Kirby, J. C. Sherris and M. Truck, Am. J. Clin. Pathol, 45, 1966, 493.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.