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2014 | 41 | 2 | 169-180
Article title

Ocena jakości snu w odniesieniu do stężenia serotoniny i melatoniny w surowicy u osób z marskością wątroby

Content
Title variants
EN
Evaluation of the quality of sleep in relation to serotonin and melatonin levels in patients with liver cirrhosis
Languages of publication
PL
Abstracts
EN
Sleep disorders occur in people who suffer from liver cirrhosis, this usually involves a change in the rhythm of melatonin secretion and its metabolism. Delayed sleep phase syndrome does not always correlate with the degree of liver damage, indicating the involvement of other factors in its pathogenesis. The aim of the study was to estimate the correlation between the night secretion of the serotonin and melatonin and the degree of sleep disorders. There were 60 patients with liver cirrhosis and 30 healthy subjects (control group) included in the study. Compared to the control group, in the first stage of hepatic encephalopathy (according to West Haven Scale) at 2 o’clock a.m. a low serum melatonin level was observed (57.5±10.2 pg/mL and 41.2±9.4 pg/mL, p<0.05) and even lower concentration of serotonin (171.2±45.0 and 108.4±29.3 μg/mL, p<0.01). These results negatively correlated with the degree of sleep disorders. The obtained results indicate that in patients with liver cirrhosis the changes in the homeostasis of both serotonin and melatonin occur, which can cause sleep disorders.
PL
U osób z marskością wątroby występują zaburzenia snu, co zwykle wiąże się ze zmianą rytmu wydzielania melatoniny i jej metabolizmu. Zespół opóźnionej fazy snu nie zawsze koreluje ze stopniem uszkodzenia wątroby, co wskazuje na udział innych czynników w jego patogenezie. Celem badania było określenie zależności między nocnym wydzielaniem serotoniny i melatoniny a stopniem zaburzeń snu. Do badań włączono 60 osób z marskością wątroby (grupa badana) i 30 osób zdrowych (grupa kontrolna). W porównaniu do grupy kontrolnej, u chorych z pierwszym stopniem encefalopatii wątrobowej (wg skali West Haven) o godzinie 2:00 stwierdzono niższe stężenie melatoniny w surowicy (odpowiednio 57,5±10,2 pg/mL i 41,2±9,4 pg/mL, p<0,05), zaś u osób z drugim stopniem encefalopatii - niższe stężenie serotoniny (odpowiednio 171,2±45,0 i 108,4±29,3
Discipline
Publisher

Year
Volume
41
Issue
2
Pages
169-180
Physical description
Contributors
  • Zakład Żywienia Klinicznego i Diagnostyki Gastroenterologicznej, Uniwersytet Medyczny w Łodzi
  • Klinika Gastroenterologii, Uniwersytet Medyczny w Łodzi
  • Klinika Gastroenterologii, Uniwersytet Medyczny w Łodzi
  • Zakład Żywienia Klinicznego i Diagnostyki Gastroenterologicznej, Uniwersytet Medyczny w Łodzi
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Document Type
paper
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-a64f4094-fadb-419e-88e7-46c0cd13337b
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