PL EN


Preferences help
enabled [disable] Abstract
Number of results
2019 | 117 | 29-43
Article title

Synthesis and biological activity of pyrazole and 1,2,3-triazole containing heterocyclic compounds

Content
Title variants
Languages of publication
EN
Abstracts
EN
As heterocyclic compounds show good biological activity, we have synthesized nitrogen containing compounds among them 9a, 9c, 9e and 9f have shown very good antimicrobial activity with remarkable inhibition zones. N'-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide (9a-i, 10) was synthesized from 5-(aryloxy)-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and 5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide by condensation in acidic media. 5-(aryloxy)-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and 5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide were synthesized from phenyl hydrazine and substituted anilines respectively. All intermediates and final compounds were confirmed by 1H-NMR, 13C-NMR, Mass Spectroscopy methods and compound 9c was confirmed by single XRD analysis.
Keywords
Year
Volume
117
Pages
29-43
Physical description
Contributors
author
  • Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
  • Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
author
  • Chemical Research Laboratory, Government Polytechnic College, Palanpur, Gujarat, India
  • Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
References
  • [1] Celine Loncle. Jean Michel Brunel, Nicolas Vidal, Michel Dherbomez, Yves Letourneux, European Journal of Medicinal Chemistry, 2004, 39, 1067-1071.
  • [2] F. A. Yassin, Journal of Microbiology and Antimicrobials, October 2010, 2(7), pp. 93-99.
  • [3] Talaat I. El-Emaryand Hassan A K Abd El-Aaland Shabaan K Mohamed, Der Chemica Sinica, 2018, 9(1), 588-598,
  • [4] K.K. Bedia, O. Elcin, U. Seda, K. Fatma, S. Nathaly, R. Sevim, A. Dimoglo, European Journal of Medicinal Chemistry, 2006, 41, 1253-1261.
  • [5] Luisa Savini, Luisa Chiasserini, Alessandra Gaeta and Cesare Pellerano, Bioorganic & Medicinal Chemistry, 2002, 10, 2193-2198.
  • [6] C. Xia, X.Y. Luo, D.J. Li, H. Lu, Z.Q. Liu, C. Jacques, Z.G. Song, Y.H. Jin. European Journal of Medicinal Chemistry, 2012, 53, 159.
  • [7] Xian-Hai Lv, Zi-Li Ren, Dong-Dong Lid, Ban-Feng Ruan, Qing-Shan Li, Ming-Jie Chu, Cheng-Ying Ai, Dao-Hong Liu, Kai Mo, Hai-Qun Cao, Chinese Chemical Letters, 2017, 28, 377-382.
  • [8] R. Mallikarjuna Rao, J. Sreeramulu, L. K. Ravindranath, G. Nagaraja Reddy, K. Hanumanthurayudu, G. Nageswara Reddy, A. Jayaraju, P. Madhusudhan, Journal of Chemical and Pharmaceutical Research, 2012, 4, 272-278.
  • [9] Jonathan A. Stefely, Rahul Palchaudhuri, Patricia A. Miller, Rebecca J. Peterson, Garrett C. Moraski, Paul J. Hergenrother and Marvin J. Miller, Journal of Medicinal Chemistry, 2010, 53, 3389-3395.
  • [10] Derek R. Buckle,Caroline J. M. Rockell, Harry Smith, and Barbara A. Spicer, Journal of Medicinal Chemistry, 1986, 29, 2262-2267.
  • [11] H. B. Lazrek,M. Taourirte, T. Oulih, J. L. Barascut, J. L. Imbach, C. Pannecouque, M. Witrouw, and E. De Clercq, NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, 2001, 20, 1949-1960.
  • [12] Nagaraj A, Sunitha M, Sanjeeva Rao L, Vani Devi M and Sanjeeva Reddy Ch. Organic Communication, 2015, 8: 3, 70-77.
  • [13] Huimin Cheng, Junting Wan, Meng-I, Lin, Yingxue Liu, Xiaoyun, Lu, Jinsong, Liu, Yong Xu, Jianxin Chen, Zhengchao Tu, Yih-Shyun E. Cheng and Ke Ding, Journal of Medicinal Chemistry, 2012, 55, 2144-2153.
  • [14] Maryam Beyrati and Alireza Hasaninejad, Organic Preparations and Procedures International, 2016, 48, 393-400. DOI: 10.1080/00304948.2016.1206426
  • [15] Vinutha, S. Madan Kumar, S. Shobhitha, B. Kalluraya,N. K. Lokanath and D. Revannasiddaiah, Acta Cryst. 2014, E70. doi: 10.1107/S1600536814007879
  • [16] Mohammad M. Mojtahedi, Mashal Javadpour, M. Saeed Abaee, Ultrasonics Sono Chemistry, 2008, 15, 828-832.
  • [17] Nithinchandra, B. Kalluraya, S. Shetty, M. Babu, J. Chem. Pharm. Res. 2013, 5, 307.
  • [18] A.C. Cunha, J.M. Figueiredo, J.L.M. Tributino, A.L.P. Miranda, H.C. Castro, R.B. Zingali, C.A.M. Fraga, M.C.B.V. de Souza, V.F. Ferreira, E.J. Barreiro, Bioorg. Med. Chem. 2003, 11, 2051.
  • [19] D.G. Diana, J.J. Nitz, Eur. Patent, 1993, 566199.
  • [20] A.F. Rostom, M.A. Shalaby, M.A. El-Demellawy. Eur. J. Med. Chem. 2003, 38, 959.
  • [21] D.R. Buckle, C.J.M. Rockell, H. Smith, B.A. Spicer. J. Med. Chem. 1986, 29, 2262.
  • [22] Shadomy, S. In Manual of Clinical Microbiology; Albert, B., Ed.; ASM Press: Washington, DC, 1991; p 1173.
  • [23] Rattan, A. Antimicrobials in Laboratory Medicine; BI Churchill Livingstone: India, 2000; p 85.
  • [24] J.W. Pflugrath 1999, Acta Cryst. D55, 1718-1725.
  • [25] Altomare, A., Cascarano, G., Giacovazzo, C., Guagliardi, A., Burla, M., Polidori, G., and Camalli, M. J. Appl. Cryst., 1994, 27, 435.
  • [26] Ibers, J. A. & Hamilton, W. C. Acta Crystallogr. 1964, 17, 781
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-a2f2bee9-aa9a-4471-96d9-f95ef28d65ac
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.