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2019 | 117 | 29-43
Article title

Synthesis and biological activity of pyrazole and 1,2,3-triazole containing heterocyclic compounds

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As heterocyclic compounds show good biological activity, we have synthesized nitrogen containing compounds among them 9a, 9c, 9e and 9f have shown very good antimicrobial activity with remarkable inhibition zones. N'-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide (9a-i, 10) was synthesized from 5-(aryloxy)-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and 5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide by condensation in acidic media. 5-(aryloxy)-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and 5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide were synthesized from phenyl hydrazine and substituted anilines respectively. All intermediates and final compounds were confirmed by 1H-NMR, 13C-NMR, Mass Spectroscopy methods and compound 9c was confirmed by single XRD analysis.
Physical description
  • Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
  • Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
  • Chemical Research Laboratory, Government Polytechnic College, Palanpur, Gujarat, India
  • Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
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