Rola wybranych czynników oreksygenicznych: oreksyny A (OXA), oreksyny B (OXB), greliny (GRE) i anoreksygenicznych: leptyny (LEP) w kontroli homeostazy organizmu w warunkach fizjologii

• Authors: Małgorzata Janas-Kozik

Title variants

EN

The role of orexigenic peptides: orexin A (OXA), orexin B (OXB), ghrelin (GRE) and anorexigenic peptide: leptin (LEP) in the control of homeostatic in the physiology

• Languages of publication: EN PL

Abstracts

EN

Hunger and satiety are closely related to the systemic homeostasis. The neurophysiology of cerebral centres controlling food intake has generally been determined. However, new peptides are still being discovered which play a significant role in the food intake process as well as food-related behaviours. In order to understand the mechanisms related to hunger and satiety in food disorders, we have to learn the physiological role peptides play in this process. The aim of the present paper is to present the orexigenic peptides: orexin A (OXA), orexin B (OXB), ghrelin (GRE) and the anorexigenic peptide: leptin (LEP), their structure, location, and systemic functions, as well as the mechanisms of their molecular activity and to follow the controlling aprocess of systemic homeostasis in the physiological conditions. The presented data make us conclude that the cooperation of orexigenic and anorexigenic peptides determines the systemic homeostasis thru controlling the hunger and satiety states, and that secretion of ghrelin and leptin in the system takes place in the form of negative feedback.

PL

Z homeostazą ustroju nierozłącznie związane jest pojęcie głodu i sytości. Neurofizjologia ośrodków mózgowych kontrolujących przyjmowanie pokarmu w zasadzie została ustalona, nadal jednak odkrywane są kolejne peptydy, które odgrywają znaczącą rolę zarówno w odżywianiu, jak i w zachowaniach związanych z jedzeniem. Aby poznać mechanizmy związane z głodem i sytością działające w zaburzeniach odżywiania, należy zrozumieć fizjologiczną rolę peptydów biorących udział w tej regulacji. Celem pracy jest przedstawienie roli peptydów oreksygenicznych: oreksyny A (OXA), oreksyny B (OXB), greliny (GRE) i peptydu anoreksygenicznego – leptyny (LEP) w przedmiocie ich budowy, lokalizacji i funkcji w ustroju, jak również mechanizmów molekularnego działania oraz prześledzenie procesu kontroli homeostazy w warunkach fizjologii. Dane przedstawione w niniejszej pracy obligują do wysunięcia wniosków, iż współdziałanie peptydów oreksygenicznych i anoreksygenicznych warunkuje homeostazę organizmu poprzez kontrolę głodu i sytości, a wydzielanie greliny i leptyny w ustroju odbywa się na zasadzie ujemnego sprzężenia zwrotnego.

Keywords

EN

anorexigenic peptides; głód; homeostaza ustroju; hunger; hunger and satiety control; kontrola głodu i sytości; orexigenic peptides; peptydy anoreksygeniczne; peptydy oreksygeniczne; satiety; systemic homeostasis; sytość

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Communications
• Journal: Psychiatria i Psychologia Kliniczna
• Year: 2005
• Volume: 5
• Issue: 2
• Pages: 87-94

Contributors

author

Małgorzata Janas-Kozik

• Katedra i Klinika Psychiatrii i Psychoterapii SAM w Katowicach Oddział Psychiatrii i Psychoterapii Wieku Rozwojowego - Centrum Pediatrii w Sosnowcu

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• Document Type: article