Before microorganisms were discovered as the causative agents of diseases, it was taught that diseases occur as a result of an imbalance in energy channels within the body system. With the advent of antimicrobials drugs to cure these diseases in both humans and animals, these antimicrobial drugs turn out to be ineffective as a result of overuse and misuse that lead to antimicrobial resistance. Antimicrobials resistance is a silent pandemic having high morbidity and mortality that result in the death of over 1.2 million people worldwide as of 2019. Antimicrobial drugs are meant to prevent and treat disease but as a result of irrational usage, they pose great risks to humans, animals, and also the environment. This resistance is the major cause of persistent diseases and there is a need to avert its transmission and prevent further occurrence through a multidisciplinary approach, approaches to vaccine design and development, and also strengthening health care services delivery.