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2016 | 30 | 1-13
Article title

Treating the 7,12-dimethylbenz(a)anthracene (DMBA) induced buccal pouch carcinoma in Syrian hamster, Mesocricetus auratus (L) with ethanolic extractives of leaves of mulberry, Morus alba (L).

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EN
The leaf extract of mulberry, Morus alba (L) in ethanol was used to treat the 7,12-dimethylbenz-anthracene (DMBA) - induced carcinoma in the buccal pouch of Syrian hamster, Mesocricetus auratus (L). The 0.5 percent DMBA in liquid paraffin was used for painting the buccal pouch. The DMBA treatment was carried thrice a week for 14 weeks. This was resulted into squamous cell carcinoma. The parameters analyzed include: The tumor incidence, volume and burden. It was followed by oral treatment with ethanolic extractives of mulberry leaves (TpEt) at a dosage of 300 mg/kg, body weight, to DMBA (on alternate days for 14 weeks)- painted animals. Administration of ethanolic extractive of mulberry leaves was found preventing significantly the incidence, volume and burden of the buccal pouch carcinoma. The ethanolic extractive of mulberry leaves exhibited significant effect, especially, the antilipidperoxidation and antioxidative enhancement in DMBA individuals of Syrian hamsters. The results are demonstrating the potency of ethanolic extractive of mulberry leaves for chemoprevention and significant antilipidperoxidative influence in 7,12-dimethylbenz-anthracene (DMBA)- induced carcinoma in the buccal pouch of Syrian hamster, Mesocricetus auratus (L). The activation of caspase through release of cytochrome C through disruption of mitochondrial membrane potential may be the sequence of action of the active principles of mulberry leaf extractives. With it’s bioactive compounds, mulberry, Morus alba (L) may open a new avenue in the cancer prevention and treatment. Taken together, the present attempt provide experimental evidence that leaves of mulberry may have chemopreventive effects on cancerous growth. Mulberry, Morus alba (L) may provide a therapeutic option for controlling the growth of cancer cells.
Year
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30
Pages
1-13
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Contributors
  • Department of Zoology, Shardabai Pawar Mahila Mahavidyalaya, Shardanagar Tal. Baramati, Dist. Pune - 413115, India
author
  • UNC School of Medicine, Yale School of Medicine, University of North Carolina, Chapel Hill, NC, USA
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article
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YADDA identifier
bwmeta1.element.psjd-9e22fdbb-43e7-442f-b9fe-0a2e1d297b39
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