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2012 | 66 | 2 | 59–65
Article title

Ciecze jonowe – nowe możliwości w syntezie substancji leczniczych

Content
Title variants
EN
Ionic liquids – new possibilities in synthesis of pharmaceutical compounds
Languages of publication
PL
Abstracts
EN
The industrial synthesis of active pharmaceutical ingredients (API) often involves a multistage process. The fi nal pharmaceutical product is at high risk of being contaminated by various organic ingredients. In recent years, ionic liquids (ILs) have become alternatives for the volatile organic solvents. Their application instead of conventional solvents as a reaction medium enables to solve problem with low-purity synthesis of pharmaceutical compounds. In this review a new application of ILs in pharmaceutical synthesis in laboratory-scale was described.
PL
Synteza farmakologicznie aktywnych związków na skalę przemysłową jest często procesem wieloetapowym, wymagającym użycia organicznych rozpuszczalników, co wiąże się z ryzykiem zanieczyszczenia końcowego produktu (substancji leczniczej) związkami organicznymi. W ostatnich latach ciecze jonowe (ionic liquids – ILs) stały się alternatywą dla organicznych lotnych rozpuszczalników. Zastosowanie ILs jako środowiska reakcji zamiast konwencjonalnych rozpuszczalników umożliwia rozwiązanie problemu zanieczyszczenia leków na etapie syntezy. W pracy opisano nowe aplikacje ILs w syntezie substancji leczniczych na skalę laboratoryjną.
Discipline
Publisher

Year
Volume
66
Issue
2
Pages
59–65
Physical description
Contributors
  • Katedra i Zakład Chemii Leków Wydziału Farmaceutycznego Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu
  • Katedra i Zakład Chemii Leków Wydziału Farmaceutycznego Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu
  • Katedra i Zakład Chemii Leków Wydziału Farmaceutycznego Collegium Medicum im. L Rydygiera w Bydgoszczy ul. Jurasza 9 85-094 Bydgoszcz tel. 52 5853540/3532 fax 52 5853529 e-mail: mmars@cm., mmars@cm.umk.pl
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Document Type
article
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YADDA identifier
bwmeta1.element.psjd-9df9b608-73d4-4bb7-adb1-971de70bda00
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