Protective effects of melatonin against oxidative damage of macromolecules caused by selected potential carcinogens

• Authors: Małgorzata Karbownik-Lewińska , Andrzej Lewiński

Title variants

PL

Ochronny wpływ melatoniny przed uszkodzeniem oksydacyjnym makrocząsteczek biologicznych wywołanym przez potencjalne czynniki kancerogenne

• Languages of publication: EN

Abstracts

EN

Reactive oxygen species (ROS) and free radicals are essential for physiological processes in living organisms. However, an overproduction of ROS and free radicals results in enhanced oxidative stress and can lead to several diseases, cancer included. Certain carcinogens may produce ROS, which directly damage macromolecules, leading to cancer initiation. It is expected that melatonin, as a well documented antioxidant, may protect macromolecules against oxidative damage caused by certain carcinogens possessing prooxidative properties. Experimental evidence for the subject in question has been discussed in the survey.

PL

Reaktywne formy tlenu (ROS) i wolne rodniki odgrywają istotną rolę w przebiegu procesów fizjologicznych w organizmach Ŝywych. Nadmierne wytwarzanie ROS i wolnych rodników moŜe jednakŜe prowadzić do nasilenia stresu oksydacyjnego i – w efekcie – do wyindukowania wielu chorób, w tym nowotworów złośliwych. Niektóre kancerogeny mogą indukować wytwarzanie ROS, które – następnie – uszkadzają makrocząsteczki w sposób bezpośredni, wiodąc do inicjacji nowotworzenia. UwaŜa się, Ŝe melatonina, jako dobrze udokumentowana substancja antyoksydacyjna, moŜe zapobiegać uszkodzeniom oksydacyjnym makrocząsteczek wywołanym przez niektóre kancerogeny posiadające właściwości prooksydacyjne; w pracy przedstawiono dowody doświadczalne dotyczące powyŜszych efektów melatoniny.

Keywords

EN

carcinogen; kancerogen; macromolecules; makromolekuły; melatonin; melatonina; ochronny; oxidative damage; protective; uszkodzenia oksydacyjne

Discipline

• MEDICINE: MEDICINE

• Publisher: Łódzkie Towarzystwo Naukowe
• Journal: Folia Medica Lodziensia
• Year: 2010
• Volume: 37
• Issue: 1
• Pages: 57-67

Contributors

author

Małgorzata Karbownik-Lewińska

• Department of Oncological Endocrinology, Medical University of Lodz, Poland, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland

author

Andrzej Lewiński

• Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Poland, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland

References

• Dreher D and Junod AF. Role of oxygen free radicals in cancer development. Eur J Cancer. 1996; 32A:30-38.
• Dröge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002; 82:47–95.
• Karbownik-Lewińska M, Kokoszko A, Jozefiak M, Lewiński A. Significance of increased lipid peroxidation in critically ill patients. Neuroendocrinol Lett. 2007; 28:367-381.
• Kokoszko A, Karbownik M, Lewiński A. Increased lipid peroxidation in growth hormone-deficient adult patients. Neuroendocrinol Lett. 2006; 27:225-230.
• Karbownik-Lewinska M, Kokoszko A, Lewandowski KC, Shalet SM, Lewinski A. GH replacement reduces increased lipid peroxidation in GH deficient adults. Clin Endocrinol (Oxf). 2008; 68:957-964.
• Szosland J, Kokoszko A, Zasada K, Stępniak J, Lewiński A, Karbownik-Lewińska M. Otyłość jako czynnik ryzyka uszkodzeń oksydacyjnych lipidów błon komórkowych u kobiet w okresie pomenopauzalnym. Przegl Menop. 2010; 3:159 164.
• Karbownik M, Lewiński A. Melatonin reduces Fenton reaction-induced lipid peroxidation in porcine thyroid tissue. J Cell Biochem. 2003; 90:806-811.
• Karbownik-Lewinska M, Stępniak J, Krawczyk J, Zasada K, Szosland J, Gesing A et al. External hydrogen peroxide is not indispensable for experimental induction of lipid peroxidation via Fenton reaction in porcine ovary homogenates. Neuroendocrinol Lett. 2010; 31, in press.
• Kvetnoy IM. Extrapineal melatonin in pathology: new perspectives for diagnosis, prognosis, and treatment of illness. Neuroendocrinol Lett. 2002; 23:92-96.
• Reiter RJ, Tan DX, Terron MP, Flores LJ, Czarnocki Z. Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions. Acta Biochim Pol. 2007; 54:1-9.
• Tan DX, Manchester LC, Hardeland R, Lopez-Burillo S, Mayo JC, Sainz RM et al. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res. 2003; 34:75-78.
• Reiter RJ. Melatonin, active oxygen species and neurological damage. Drug News Perspect. 1998; 11:291-296.
• Reiter RJ, Calvo JR, Karbownik M, Qi W, Tan DX. Melatonin and its relation to the immune system and inflammation. Ann N Y Acad Sci. 2000; 917:376-386.
• Hardeland R & Pandi-Perumal SR. Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug. Nutr Metab (Lond) 2005; 2, 22 (doi: 10.1186/1743-7075-2-22).
• Karbownik M, Reiter RJ, Garcia JJ, Cabrera J, Burkhardt S, Osuna C et al. Indole-3-propionic acid, a melatonin-related molecule, protects hepatic microsomal membranes from iron-induced oxidative damage: relevance to cancer reduction. J Cell Biochem 2001; 81:507-513.
• Karbownik M and Reiter RJ. Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proc Soc Exp Biol Med 2000; 225:9-22.
• Karbownik M, Reiter RJ. Melatonin protects against oxidative stress caused by delta-aminolevulinic acid: implications for cancer reduction. Cancer Invest. 2002; 20:276-286.
• Drobnik J, Karbownik-Lewińska M, Szczepanowska A, Słotwińska D, Olczak S, Jakubowski L et al. Regulatory influence of melatonin on collagen accumulation in the infarcted heart scar. J Pineal Res. 2008; 45:285-290.
• Karasek M. Melatonin, human aging, and age-related diseases. Exp Gerontol. 2004; 39:1723-1729.
• Karasek M. Does melatonin play a role in aging processes? J Physiol Pharmacol. 2007; 58:105-113.
• Karasek M, Winczyk K. Melatonin in humans. J Physiol Pharmacol. 2006; 57:19 39
• Korkmaz A, Topal T, Tan DX, Reiter RJ. Role of melatonin in metabolic regulation. Rev Endocr Metab Disord. 2009; 10:261-270.
• Sánchez-Barceló EJ, Mediavilla MD, Tan DX, Reiter RJ. Clinical uses of melatonin: evaluation of human trials. Curr Med Chem. 2010; 17:2070-2095.
• Gałecki P, Szemraj J, Bartosz G, Bieńkiewicz M, Gałecka E, Florkowski A et al. Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. J Pineal Res. 2010; 48:311 317.
• Reiter RJ, Tan DX, Fuentes-Broto L. Melatonin: a multitasking molecule. Prog Brain Res. 2010; 181:127-151.
• Floyd RA The role of 8-hydroxydeoxyguanosine in carcinogenesis. Carcinogenesis. 1990; 11:1447-1450.
• Burcham PC Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts. Mutagenesis. 1998; 13:287-305.
• Garcia JJ, Reiter RJ, Guerrero JM, Escames G, Yu BP, Oh CS et al. Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Lett. 1997; 408:297-300.
• Stevens RG, Jones DY, Micozzi MS. and Taylor PR Body iron stores and the risk of cancer. N Engl J Med. 1988; 319:1047-1052.
• Karbownik M, Gitto E, Lewiński A and Reiter RJ. Relative efficacies of indole antioxidants in reducing autoxidation and iron-induced lipid peroxidation in testes: implications for cancer initiation. J Cell Biochem. 2001; 81:693-699.
• García JJ, Reiter RJ, Ortiz GG, Oh CS, Tang L, Yu BP et al. Melatonin enhances tamoxifen's ability to prevent the reduction in microsomal membrane fluidity induced by lipid peroxidation. J Membr Biol. 1998; 162:59-65.
• Linet MS, Gridley G, Nyrén O, Mellemkjaer L, Olsen JH, Keehn S et al. Primary liver cancer, other malignancies, and mortality risks following porphyria: a cohort study in Denmark and Sweden. Am J Epidemiol 1999; 149:1010-1015
• Karbownik M, Reiter RJ, Garcia JJ, Tan D-X, Qi W and Manchester LC. Melatonin reduces rat hepatic macromolecular damage due to oxidative stress caused by  aminolevulinic acid. Biochim Biophys Acta 2000; 1523:140-146.
• Karbownik M, Tan D-X, Manchester LC and Reiter RJ. Renal toxicity of the carcinogen -aminolevulinic acid: Antioxidant effects of melatonin. Cancer Lett. 2000; 161:1-7.
• Karbownik M, Tan DX and Reiter RJ. Melatonin reduces the oxidation of nuclear DNA and membrane lipids induced by the carcinogen -aminolevulinic acid. Int J Cancer. 2000; 88:7-11.
• Parodi S, De Flora S, Cavanna M, Pino A, Robbiano L, Bennicelli C et al. DNA-damaging activity in vivo and bacterial mutagenicity of sixteen hydrazine derivatives as related quantitatively to their carcinogenicity. Cancer Res. 1981; 41:1469-1482.
• Karbownik M, Reiter RJ, Garcia JJ and Tan D-X. Melatonin reduces phenyl-hydrazine-induced oxidative damage to cellular membranes: evidence for the involvement of iron. Int J Biochem Cell Biol. 2000; 32:1045-1054.
• Vijayalaxmi, Reiter RJ, Meltz ML. Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutat Res. 199; 346:23-31.
• Karbownik M, Reiter RJ, Qi W, Garcia JJ, Tan D-X, Manchester LC et al. Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation. Mol Cell Biochem. 2000; 211:137-144.
• Qi W, Reiter RJ, Tan DX, Garcia JJ, Manchester LC, Karbownik M et al. Chromium(III)-induced 8-hydroxydeoxyguanosine in DNA and its reduction by antioxidants: comparative effects of melatonin, ascorbate, and vitamin E. Environ Health Perspect. 2000; 108:399-402.
• Karbownik M, Garcia JJ, Lewiński A and Reiter RJ Carcinogen-induced, free radical-mediated reduction in microsomal membrane fluidity: reversal by indole-3-propionic acid. J Bioenerg Biomembr. 2001; 33:73-78.
• Stohs SJ, Bagchi D, Hassoun E and Bagchi M Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Oncol. 2000; 19:201-213.
• Karbownik M, Gitto E, Lewinski A, Reiter RJ. Induction of lipid peroxidation in hamster organs by the carcinogen cadmium: melioration by melatonin. Cell Biol Toxicol. 2001; 17:33-40.
• Liehr JG. Is estradiol a genotoxic mutagenic carcinogen? Endocrine Rev. 2000; 21:40-54.
• Karbownik M, Reiter RJ, Burkhardt S, Gitto E, Tan D-X and Lewiński Melatonin attenuates estradiol-induced oxidative damage to DNA: relevance for cancer prevention. Exp Biol Med (Maywood). 2001; 226:707-712.
• Karbownik M, Reiter RJ, Cabrera J and Garcia JJ. Comparison of the protective effect of melatonin with other antioxidants in the hamster kidney model of estradiol-induced DNA damage. Mutat Res. 2001; 474:87-92.
• Stasiak M, Lewiński A, Karbownik-Lewińska M. Relationship between toxic effects of potassium bromate and endocrine glands. Endokrynol Pol. 2009; 60:40 50.
• Karbownik M, Stasiak M, Zasada K, Zygmunt A, Lewinski A. Comparison of potential protective effects of melatonin, indole-3-propionic acid, and propyl-thiouracil against lipid peroxidation caused by potassium bromate in the thyroid gland. J Cell Biochem. 2005; 95:131-138.
• Karbownik M, Stasiak M, Zygmunt A, Zasada K, Lewiński A. Protective effects of melatonin and indole-3-propionic acid against lipid peroxidation, caused by potassium bromate in the rat kidney. Cell Biochem Funct. 2006; 24:483-489.
• Stasiak M, Zasada K, Lewinski A, Karbownik-Lewinska M. Melatonin restores the basal level of lipid peroxidation in rat tissues exposed to potassium bromate in vitro. Neuroendocrinol Lett. 2010; 31:363-369.
• Daniels JM, Liu L, Stewart RK, Massey TE. Biotransformation of aflatoxin B1 in rabbit lung and liver microsomes. Carcinogenesis. 1990; 11:823-827.
• Gesing A, Karbownik-Lewinska M. Protective effects of melatonin and N acetylserotonin on aflatoxin B1-induced lipid peroxidation in rats. Cell Biochem Funct. 2008; 26:314-319.

• Document Type: paper